摘要
手性农药对映体在防除各类有害生物时常表现出不同的生物活性,关注手性农药对映体的选择活性对于促进农药减施增效、发展绿色农业具有重要意义。本文综述了手性农药对映体选择活性研究现状,并将对映体的选择活性机制研究归纳为两方面:一方面大多数研究采用计算机模拟技术,分析对映体与靶标分子活性位点之间的结合能力,仅有少部分研究通过生物试验验证了分子对接的结果;另一方面研究则通过放射性同位素示踪法以及定量分析代谢物等手段,探究手性农药对映体在生物系统内吸收、运输和代谢的差异。本文旨在为识别高活性手性农药单体、开发高效低风险新型绿色农药提供参考。
Chiral pesticide enantiomers often show different bioactivity in controlling harmful organisms.It is of great significance to pay attention to the selective activity of chiral pesticide enantiomers to promote the reduction and efficiency of pesticides and to develop green agriculture.In this paper,according to the research status of enantioselective activity of chiral pesticides,the research on enantioselective activity mechanism is summarized into two aspects:On the one hand,computer simulation technology is used to analyze the binding ability between enantiomers and active sites of target molecules,and a few of them have also carried out biological experiments;on the other hand,the study explored the differences in absorption,transportation and metabolism of chiral pesticide enantiomers in biological systems by means of radioisotope tracing and quantitative analysis of metabolites.This paper aims to provide reference for the identification of highly active activity chiral pesticide monomers and the development of new green pesticides with high efficiency and low risk.
作者
朱俊琪
李远富
毛凯凯
谢发扬
谭辉华
赵锋
ZHU Junqi;LI Yuanfu;MAO Kaikai;XIE Fayang;TAN Huihua;ZHAO Feng(Guangxi Key Laboratory of Agro-environment and Agric-products Safety,Guangxi University,Nanning 530004,China)
出处
《农药学学报》
CAS
CSCD
北大核心
2024年第3期427-439,共13页
Chinese Journal of Pesticide Science
基金
国家自然科学基金-青年科学基金项目(32302398)
广西科技计划项目-青年创新人才科研专项(2022AC21245)。
关键词
手性农药
对映体
立体选择性
生物活性
机制
chiral pesticides
enantiomers
enantioselective activity
bioactivity
mechanism
