摘要
目的:分析靶向治疗联合放化疗在肺癌脑转移患者中的应用效果。方法:选取2021年1月—2023年1月滨州市中心医院收治的80例肺癌脑转移患者作为研究对象,随机分为对照组和观察组,各40例。对照组实施标准的放化疗方案,观察组在对照组基础上实施靶向治疗。比较两组治疗效果。结果:观察组总控制率高于对照组,差异有统计学意义(P=0.023)。治疗后,两组血管内皮生长因子A、血管内皮生长因子B、乳酸脱氢酶、癌胚抗原水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组局部复发率、远端转移率低于对照组,差异有统计学意义(P<0.05)。观察组不良反应总发生率低于对照组,差异有统计学意义(P=0.039)。结论:靶向治疗联合放化疗在肺癌脑转移患者中的应用效果显著,可改善病理指标,降低局部复发率、远端转移率、不良反应总发生率。
Objective:To analyze the application effect of targeted therapy combined with chemoradiotherapy in the patients with brain metastasis of lung cancer.Methods:Eighty patients with brain metastasis of lung cancer treated at Binzhou Central Hospital from January 2021 to January 2023 were selected as the study subjects.They were randomly divided into control group and observation group with 40 cases in each group.The control group received standard chemoradiotherapy regimen and the observation group received targeted therapy on the basis of the control group.The treatment effects of the two groups were compared.Results:The total control rate in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.023).After treatment,the levels of vascular endothelial growth factor A,vascular endothelial growth factor B,lactate dehydrogenase and carcinoembryonic antigen in the two groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group,with a statistically significant difference(P<0.05).The local recurrence rate and distal metastasis rate in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P=0.039).Conclusion:The application of targeted therapy combined with chemoradiotherapy in patients with brain metastasis of lung cancer has a significant effect,which can improve pathological indexes,reduce the local recurrence rate,distant metastasis rate and total incidence of adverse reactions.
作者
崔洪霞
娄秀娥
邓亭
Cui Hongxia;Lou Xiu'e;Deng Ting(Department of Oncology,Binzhou Central Hospital,Binzhou 251700,Shandong Province,China;Department of Geriatric Medicine,Binzhou Central Hospital,Binzhou 251700,Shandong Province,China)
出处
《中国社区医师》
2024年第14期70-72,共3页
Chinese Community Doctors
关键词
肺癌脑转移
靶向治疗
放化疗
Brain metastasis of lung cancer
Targeted therapy
Chemoradiotherapy
