摘要
器官纤维化是指正常组织的瘢痕形成和过度胶原沉积导致器官功能障碍甚至衰竭.组蛋白去乙酰化酶3(HDAC3)是一种组蛋白修饰酶,通过去除组蛋白上的乙酰基团进行表观遗传修饰来抑制基因表达.研究表明,HDAC3参与调控器官纤维化的发生发展.本文就HDAC3致器官纤维化作用的研究进展进行综述,为器官纤维化临床治疗提供新的思路.
Organ fibrosis refers to the formation of scar and excessive collagen deposition in normal tissue leading to organ dysfunction and even failure.Histone deacetylase 3(HDAC3)is a histone modifying enzyme that inhibits gene expression by epigenetic modification by removing acetyl groups from histone.Studies have shown that HDAC3 is involved in regulating the occurrence and development of organ fibrosis.This article reviews the research progress of HDAC3-induced organ fibrosis in order to provide new ideas for clinical treatment of organ fibrosis.
作者
张天宇
卢潇
丁崧
邹诗施
李宁
江万里
耿庆
Zhang Tianyu;Lu Xiao;Ding Song;Zou Shishi;Li Ning;Jiang Wanli;Geng Qing(Department of Thoracic Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,China)
出处
《中华实验外科杂志》
CAS
2024年第5期1116-1118,共3页
Chinese Journal of Experimental Surgery
基金
国家自然科学基金(81770095,8210082163)
中央高校基本科研专项基金(2042021kf0081)
湖北省自然科学基金创新群体(2020CFA027)
武汉大学人民医院跨学科创新型人才基金资助项目(JCRCWL-2022-002)。
