摘要
目的:基于古今医案云平台(V2.2.3)分析从建库以来中医药治疗胰腺炎的用药规律,为胰腺炎的治疗提供参考。方法:检索中国知网、万方、维普、PubMed等数据库中收录的中医药治疗胰腺炎的临床研究文献,建立文献数据库,运用古今医案云平台(V2.2.3)对中医药治疗胰腺炎的处方进行药物使用频次分析、功效分类分析、性味归经分析、关联规则分析、聚类分析、中医证候分析及证型-中药分析,总结出中医药在临床中治疗胰腺炎的思路。结果:共纳入符合标准的中药复方147首,涉及中药199味,功效分类以清热解毒、疏肝解郁、清热燥湿最为常见;高频药物34味,其中柴胡、黄芩、生大黄、枳实、白芍、厚朴、茯苓使用频次较多;药性以微寒、温为主,药味以苦、辛为主,多归脾经、肝经、胃经;高频中药聚类得到5个药物组合;关联规则分析得到17条关联强度较高的药物组合;证候分析得到以脾、阳明、少阳为主的9个病位证素,以热、湿、血瘀、气滞为主的14个病性证素,以及以湿热证、气滞证、血瘀证、脾虚证、阳明证为主的22个证型;证型-中药分析得到6个复杂网络分布图,以柴胡、生大黄、黄芩与证型关联的频次最高。结论:现代中医医家治疗胰腺炎以大柴胡汤化裁为核心处方,辨证用药主要以疏肝理气、通腑泻热、健脾和胃、活血化瘀为法。
Objective:Based on the ancient and modern medical record cloud platform(V2.2.3),the medication patterns of traditional Chinese medicine in treating pancreatitis since the establishment of databases were analyzed to provide reference for the treatment of pancreatitis.Method:Retrieve clinical research literature on the treatment of pancreatitis in traditional Chinese medicine was retrieved from CNKI,Wanfang Database,VIP Database,and PubMed Database to establish a literature database,and the ancient and modern medical record cloud platform(V2.2.3)was used to conduct data mining on the frequency of drug use,efficacy classification,property and taste tropism,association rule analysis,cluster analysis,traditional Chinese medicine syndrome analysis,and syndrome type-traditional Chinese medicine analysis to summarize the ideas of traditional Chinese medicine in treating pancreatitis in clinical practice.Results:The results included a total of 147 Chinese herbal formulas that met the standards,involving 199 traditional Chinese medicines.The most common efficacy categories were clearing heat and detoxifying,soothing liver and relieving depression,and clearing heat and dampness.There are 34 high-frequency drugs,among which Chaihu(Radix Bupleuri),Huangqin(Radix Scutellariae),Shengdahuang(Radix et Rhizoma Rhei),Zhishi(Fructus Aurantii Immaturus),Baishao(Radix Paeoniae Alba),Houpo(Cortex Magnoliae Officinalis),and Fuling(Poria)were used more frequently.The medicinal properties were mainly mild cold and warm,and the medicinal tastes were mainly bitter and spicy,mostly belonging to the spleen,liver,and stomach meridians.High frequency clustering of traditional Chinese medicine obtained 5 drug combinations.Association rule analysis obtained 17 drug combinations with high association strength.Syndrome analysis revealed 9 disease location syndrome elements with spleen,Yangming(阳明),and Shaoyang(少阳)as the main symptoms,14 disease type syndrome elements with heat,dampness,blood stasis,and Qi(气)stagnation as the main symptoms,and 22 syndrome types with dampness heat syndrome,Qi stagnation syndrome,blood stasis syndrome,spleen deficiency syndrome,and Yangming syndrome as the main symptoms.The analysis of syndrome types-traditional Chinese medicine yielded six complex network distribution maps,with Chaihu,shengdahuang,and Huangqin having the highest frequency of association with syndrome types.Conclusion:Modern traditional Chinese medicine doctors treat pancreatitis with the Dachaihu decoction(大柴胡汤)as the core prescription,and the main methods of differential medication are to soothe the liver and regulate Qi,clear the internal organs and heat,strengthen the spleen and stomach,and promote blood circulation and blood stasis.
出处
《中医临床研究》
2024年第16期69-75,126,共8页
Clinical Journal Of Chinese Medicine
基金
云南省中医联合专项青年项目[2019FF002(-083)]
云南省中医联合专项面上项目(202101AZ070001-024)。
关键词
胰腺炎
中医药
数据挖掘
用药规律
Pancreatitis
Traditional Chinese medicine
Data mining
Medication rule
