摘要
目的 对本院收治的营养干预对生长迟缓患儿血清IGF-1水平的影响进行分析,为生长迟缓患儿营养干预措施的制定与优化提供依据。方法 以本院2021年4月-2022年4月期间就诊的40例0~3岁生长迟缓患儿作为观察组,同时选取40例0~3岁的正常儿童作为对照组。对观察组患儿进行营养干预,测定干预前后观察组患儿血清IGF-1水平相关生长指标,以对照组为参考,比较2组各项指标。结果 营养干预前,观察组血清IGF-1水平显著低于对照组(P<0.05)营养干预后,观察组血清IGF-1水平显著高于本组营养干预前差异有统计学意义(P<0.05),且与同时段的对照组相当差异无统计学意义(P>0.05)。此外,观察组营养干预后的生长指标(HtSDS、生长速率)均显著优于营养干预前差异有统计学意义(P<0.05)。结论 血清IGF-1水平是判断儿童生长迟缓情况的重要指标,通过早期个性化的营养干预可提升生长迟缓患儿血清IGF-1水平,促进其生长发育。
Objective To analyze the effect of nutritional intervention on serum insulin-like growth factor-1(IGF-1)levels in children with growth retardation,and to provide basis for the formulation and optimization of nutritional intervention measures for children with growth retardation.Methods A total of 40 children with growth retardation aged 0~3 years who were treated in our hospital from April 2021 to April 2022 were selected as the observation group,and 40 normal children aged 0~3 years were selected as the control group.The children in the observation group performed nutritional intervention,measured the serum IGF-1 level and related growth indexes before and after the intervention,and compared the indicators of the two groups with the control group as a reference.Results Before nutritional intervention,the serum IGF-1 level in the observation group was significantly lower than that in the control group(P<0.05).After nutritional intervention,the serum IGF-1 level was significantly higher than that before nutritional intervention(P<0.05),with statistical significance(P<0.05),and it was similar to the control group in the same period(P>0.05),without statistical significance.In addition,the growth and development indexes of the observation group after nutritional intervention were significantly better than those before nutritional intervention,and the difference was statistically significant(P<0.05).Conclusions Serum IGF-1 level is an important indicator for judging the growth retardation in children.Early personalized nutritional intervention can increase the serum IGF-1 level and promote growth and development of children with growth retardation.
作者
朱丽虹
陈晓琴
谢露
李瑶
郭碧舟
ZHU Lihong;CHEN Xiaoqin;XIE Lu;LI Yao;GUO Bizhou(Pediatric Department,Maternal and Child Care Service Center of Kunming,Kunming Yunnan 650000,China)
出处
《云南医药》
CAS
2024年第3期19-22,共4页
Medicine and Pharmacy of Yunnan
基金
昆明市卫健委科研项目(2021-06-01-0010)。
关键词
营养干预
生长迟缓
血清胰岛素样生长因子
nutritional intervention
growth retardation
serum insulin-like growth factor-1(IGF-1)
