摘要
目的 探究AH患儿应用孟鲁司特钠、糠酸莫米松鼻喷雾剂的临床疗效。方法 按照随机数字表法从2021年1月-2023年1月驻马店市中医院收治的AH患儿中选取120例,分为2组,各60例。对照组采用糠酸莫米松鼻喷雾剂治疗,观察组在此基础上采用孟鲁司特钠治疗。比较2组临床疗效、血清变态反应指标、症状评分、腺样体厚度/鼻咽腔宽度(A/N)比值及不良反应。结果 观察组治疗总有效率高于对照组;治疗后,观察组ECP、EOS、SIgE水平较低,症状总评分、A/N比值较低,差异有统计学意义(P<0.05)。且2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 AH患儿采用孟鲁司特钠联合糠酸莫米松鼻喷雾剂治疗效果显著,可降低血清变态反应指标,缓解症状,降低A/N比值,较为安全。
Objective To explore the clinical efficacy of montelukast sodium and mometasone furoate nasal spray in children with adenoid hypertrophy(AH).Methods 120 children with AH admitted to Zhumadian Traditional Chinese Medicine Hospital from January 2021 to January 2023 were selected according to random number table method and divided into two groups with 60 cases each.The control group was treated with mometasone furoate nasal spray,while the observation group was treated with montelukast sodium on this basis.Compared the clinical efficacy,serum allergy indicators,symptom scores,adenoid thickness/nasopharyngeal width(A/N)ratio and adverse reactions between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group;After treatment,the observation group had lower levels of eosinophil cationic protein(ECP),eosinophil direct count(EOS)and specific immunoglobulin E(SIgE),as well as lower total symptom score and A/N ratio,with statistically significant differences(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions The combination of montelukast sodium and mometasone furoate nasal spray has a significant therapeutic effect on children with AH,which can reduce serum allergy indicators,alleviate symptoms,reduce A/N ratio,and is relatively safe.
作者
贺书关
HE Shuguan(Otolaryngology Department,Zhumadian Traditional Chinese Medicine Hospital,Zhumadian Henan 463000,China)
出处
《云南医药》
CAS
2024年第3期34-37,共4页
Medicine and Pharmacy of Yunnan
关键词
腺样体肥大
孟鲁司特钠
糠酸莫米松鼻喷雾剂
变态反应
adenoidal hypertrophy
montelukast sodium
momosone furoate nasal spray
allergic reactions
