摘要
血管钙化是血管壁中钙盐沉积的过程,导致血管硬化和失去弹性。它通常发生在中老年人,尤其是患有动脉粥样硬化、高血压、糖尿病和慢性肾脏疾病等疾病患者。血管钙化是一个主动的过程,其中平滑肌细胞的成骨转换是重要事件之一。这些细胞在钙化过程中释放钙离子,导致钙盐的沉积,形成钙化斑块。血管钙化受多种因素调节,包括高磷、高钙水平及氧化应激、机械应力等。此外,中医药研究在减轻血管钙化方面显示出潜力,例如灵芝孢子粉和其衍生物,三七、黄芩素、根皮素、雷公藤甲素等。这些研究为进一步理解和干预血管钙化提供了重要的证据,并揭示了一些潜在的抑制因子,可以作为未来治疗血管钙化的研究方向。
Vascular calcification refers to the process of calcium salt deposition in the blood vessel wall,leading to vascular stiffening and loss of elasticity.It commonly occurs in middle-aged and elderly individuals,especially those with chronic conditions such as atherosclerosis,hypertension,diabetes,and chronic kidney disease.Vascular calcification is an active process,and one of the key events is the transdifferentiation of smooth muscle cells into osteoblast-like cells.These cells release calcium ions during the calcification process,leading to calcium salt deposition and the formation of calcified plaques.Vascular calcification is regulated by various factors,including high levels of phosphate and calcium,oxidative stress,and mechanical stress.Traditional Chinese medicine research has shown potential in attenuating vascular calcification,with substances such as Ganoderma lucidum spore powder and its derivatives,Panax notoginseng,baicalin,geniposide,and triptolide.These studies provide important evidence for further understanding and intervention in vascular calcification and reveal potential inhibitory factors that could be explored for future treatments.
作者
陈诚
张钲
彭瑜
牛小伟
CHEN Cheng;ZHANG Zheng;PENG Yu;NIU Xiaowei(The First Clinical Medical College of Lanzhou University,Lanzhou,Gansu 730000,China;Department of Cardiology,the First Hospital of Lanzhou University,Lanzhou,Gansu 730000,China;Heart Center,the First Hospital of Lanzhou University,Lanzhou,Gansu 730000,China)
出处
《中国动脉硬化杂志》
CAS
2024年第7期627-633,共7页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金项目(82000277和82060807)资助。
关键词
动脉粥样硬化
血管钙化
血管平滑肌细胞
血管平滑肌细胞成骨转换
atherosclerosis
vascular calcification
vascular smooth muscle cell
osteogenic transition of vascular smooth muscle cell
