摘要
针灸治疗慢性疲劳综合征(chronic fatigue syndrome, CFS)效果确切,其机制研究主要集中于控制炎性反应、调节免疫反应、对抗过氧化应激机制、调节神经内分泌功能等方面,对于调节线粒体代谢方面尚且不足。基于此本文检索了基于线粒体代谢机制探讨针灸治疗CFS的相关文献,结果显示,针灸调节线粒体功能从而治疗CFS是多层次、多靶点共同作用的结果。针灸可通过提高线粒体电子密度、增加线粒体数量、减少线粒体空泡化从而调节线粒体形态;针灸可通过提高线粒体呼吸链复合物Ⅰ、Ⅱ、Ⅲ和Ⅳ等活性,增加ATP含量;针灸可通过调控线粒体视神经萎缩蛋白1、线粒体融合蛋白1、线粒体动力样蛋白1表达量,恢复线粒体动力学平衡;针灸可通过降低肿瘤坏死因子-α、干扰素-γ、血清白介素-6等炎性因子含量,减轻炎症对线粒体损伤;针灸可通过升高超氧化物歧化酶、谷胱甘肽过氧化物酶,降低丙二醛含量,抑制氧化应激反应,提高线粒体代谢;针灸可通过提高单磷酸腺苷激活的蛋白激酶/过氧化物酶体增殖物活化受体γ共激活因子α表达,促进线粒体生物合成发挥治疗作用。本文对以上机制进行总结分析,以期为研究针灸治疗CFS机制方面提供新的方向。
Acupuncture has a positive effect on chronic fatigue syndrome(CFS),and its mechanism studies mainly focus on the control of inflammatory response,regulation of immune response,anti-peroxide stress mechanism,regulation of neuroendocrine function,etc.,but there is insufficient regulation of mitochondrial metabolism.Based on this,this paper reviewed the relevant literature on the treatment of CFS by acupuncture based on the mechanism of mitochondrial metabolism,and the results showed that the regulation of mitochondrial function by acupuncture to treat CFS was the result of multi-level and multi-target interaction.Acupuncture could improve mitochondrial morphology by increasing mitochondrial electron density,increasing mitochondrial number and reducing mitochondrial vacuolation.Acupuncture could increase the activity of mitochondrial respiratory chain complexⅠ,Ⅱ,ⅢandⅣand increase the content of ATP.Acupuncture restored the mitochondrial dynamic balance by regulating the expression levels of fusion protein OPA1,MFN1 and fission protein DRP1.Acupuncture could reduce the content of TNF-α,INF-γ,serum IL-6 and other inflammatory factors to reduce the damage of inflammation on mitochondria.Acupuncture could increase the levels of SOD and GSH-Px,decreased the level of MDA,inhibit oxidative stress and improve mitochondrial metabolism.Acupuncture played a therapeutic role by increasing the expression of AMPK/PGC-1αand promoting mitochondrial biosynthesis.In this paper,the above mechanisms were summarized and analyzed in order to provide a new direction for studying the mechanism of acupuncture treatment of CFS.
作者
张琳
马巧琳
于冬冬
崔家禾
宋甲奇
游晓阳
胡斌
ZHANG Lin;MA Qiaolin;YU Dongdong;CUI Jiahe;SONG Jiaqi;YOU Xiaoyang;HU Bin(Academy of Acupuncture and Tuina,Henan University of Traditional Chinese Medicine,Zhengzhou 450046,China)
出处
《环球中医药》
CAS
2024年第6期1199-1204,共6页
Global Traditional Chinese Medicine
基金
河南省中医药科学研究专项重点课题(2019ZY1025)
中医药传承与创新人才工程(仲景工程)中医药拔尖人才项目(豫卫中医函[2021]15号)。
关键词
针灸
慢性疲劳综合征
线粒体代谢
线粒体呼吸链
线粒体动力学
机制研究
综述
acupuncture
chronic fatigue syndrome
mitochondrial metabolism
mitochondrial respiratory chain
mitochondrial dynamics
mechanism research
review
