摘要
目的探讨血清白细胞介素-17A(IL-17A)、γ-干扰素(IFN-γ)与慢性鼻窦炎伴鼻息肉(CRSwNP)患者病情严重程度的相关性。方法以河南科技大学第一附属医院2021年6月至2023年6月收治的82例CRSwNP患者为观察组,另择同期收治的30例单纯鼻中隔偏曲的患者为对照组。于治疗前测定并对比两组血清IL-17A、IFN-γ、转化生长因子-β1(TGF-β1)、基质金属蛋白酶-9(MMP-9)水平;并采用pearson相关性分析CRSwNP患者血清IL-17A、IFN-γ与病情严重程度及血清TGF-β1、MMP-9的关系,采用受试者工作特征(ROC)曲线分析血清IL-17A、IFN-γ对CRSwNP的诊断效能。结果观察组的血清IL-17A、IFN-γ、TGF-β1、MMP-9均明显高于对照组,差异有统计学意义(P<0.05);观察组的Lund-Mackay评分、Lund-Kennedy评分均明显高于对照组,差异有统计学意义(P<0.05)。Pearson相关性分析显示,CRSwNP患者的血清IL-17A、IFN-γ水平与Lund-Mackay评分、Lund-Kennedy评分、血清TGF-β1、MMP-9水平均呈正相关关系(P<0.05);ROC曲线分析显示,血清IL-17A、IFN-γ水平及二者联合检测均对CRSwNP有诊断效能(P<0.05),且相较于单项检测,二者联合检测的效能更高,AUC为0.953,敏感度为93.90%,特异度为90.00%。结论CRSwNP的发生伴随IL-17A、IFN-γ升高,IL-17A、IFN-γ水平与病情严重程度及鼻黏膜组织重构有关,还可作为CRSwNP的早期诊断指标。
Objective To investigate the correlation between serum interleukin-17A(IL-17A),interferon-gamma(IFN-γ),and the severity of chronic rhinosinusitis with nasal polyps(CRSwNP).Methods A prospective study was conducted on 82 patients with CRSwNP admitted to the First Affiliated Hospital of Henan University of Science and Technology from June 2021 to June 2023 as the observation group,and 30 patients with isolated nasal septal deviation during the same period as the control group.Before treatment,serum levels of IL-17A,IFN-γ,transforming growth factor-beta 1(TGF-β1),and matrix metalloproteinase-9(MMP-9)were measured and compared between the two groups.Pearson correlation analysis was used to assess the correlation between serum IL-17A,IFN-γ,the severity of the disease,and serum TGF-β1,MMP-9.Receiver operating characteristic(ROC)curve analysis was performed to evaluate the diagnostic efficiency of serum IL-17A and IFN-γfor CRSwNP.Results The serum levels of IL-17A,IFN-γ,TGF-β1,and MMP-9 in the observation group were significantly higher than those in the control group,with statistical significance(P<0.05).The Lund-Mackay score and Lund-Kennedy score in the observation group were significantly higher than those in the control group(P<0.05).Pearson correlation analysis showed a positive correlation between serum IL-17A,IFN-γlevels,Lund-Mackay score,Lund-Kennedy score,serum TGF-β1,and MMP-9 in CRSwNP patients(P<0.05).ROC curve analysis demonstrated that serum IL-17A,IFN-γ,and their combined detection had diagnostic efficiency for CRSwNP(P<0.05).The combined detection showed higher efficiency than individual testing,with an AUC of 0.953,sensitivity of 93.90%,and specificity of 90.00%.Conclusion Elevated levels of IL-17A and IFN-γare associated with the occurrence of CRSwNP,and their levels correlate with the severity of the disease and nasal mucosal tissue remodeling.They can serve as early diagnostic indicators for CRSwNP.
作者
周倩
徐鹏育
曾伟
ZHOU Qian;XU Peng-yu;ZENG Wei(Department of Otolaryngology,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,Henan,China;不详)
出处
《广东医学》
CAS
2024年第5期631-635,共5页
Guangdong Medical Journal
基金
河南省医学科技攻关计划联合共建项目(LHGJ20200716)。
