摘要
目的探讨糖皮质激素冲击治疗对慢性肾脏病患者中性粒细胞和白细胞计数的影响。方法选取医院肾脏科2018年1月至2022年12月收治的行糖皮质激素冲击治疗的慢性肾脏病患者76例,根据患者是否出现感染分为感染组(25例)和未感染组(51例);未感染组患者根据激素冲击治疗前是否应用激素分为未使用激素组(35例)和使用激素组(16例),根据患者年龄分为10~19岁组(6例)、20~29岁组(13例)、40~49岁组(11例)。以激素冲击治疗前最后1次血常规检查的中性粒细胞和白细胞计数为基线值,记录激素冲击治疗期间及激素冲击治疗结束后患者中性粒细胞和白细胞计数的绝对值。结果激素冲击治疗第1,2,3天,未感染组患者的中性粒细胞和白细胞计数均显著升高(P<0.05),感染组无显著差异(P>0.05);激素冲击治疗结束后第1天,未感染组和感染组患者的中性粒细胞和白细胞计数均降至基线值(P<0.05)。使用激素组和未使用激素组患者激素冲击治疗第3天的中性粒细胞和白细胞计数均无显著差异(P>0.05),10~19岁组患者激素冲击治疗第3天的中性粒细胞和白细胞计数均显著高于20~29岁组、40~49岁组(P<0.05)。结论激素冲击治疗可使未感染患者的中性粒细胞和白细胞计数显著升高,且升高幅度受年龄因素影响,不受激素冲击治疗前是否应用激素影响。激素冲击治疗结束后的第1天,患者的中性粒细胞和白细胞计数则显著降至激素冲击治疗前的基线水平。
Objective To investigate the effect of glucocorticoids pulse therapy(GPT)on neutrophil and white blood cell counts in patients with chronic kidney disease.Methods A total of 76 patients with chronic kidney disease who underwent GPT in the nephrology department of the hospital from January 2018 to December 2022 were selected and divided into the infected group(25 cases)and the uninfected group(51 cases)based on whether they had infection.The patients in the uninfected group were divided into the non-glucocorticoid group(35 cases)and the glucocorticoid group(16 cases)based on whether glucocorticoids were used before GPT.According to the age of the patients,they were divided into the 10-19 years old group(6 cases),20-29 years old group(13 cases),and 40-49 years old group(11 cases).With the neutrophil and white blood cell counts in the last blood routine examination before GPT as the baseline level,the absolute values of neutrophil and white blood cell counts during and after GPT in patients were recorded.Results On the 1st,2nd,and 3rd day of GPT,the neutrophil and white blood cell counts of patients in the uninfected group significantly increased(P<0.05),while there was no significant difference in the infected group(P>0.05).On the 1st day after GPT,the neutrophil and white blood cell counts in the uninfected group and the infected groups decreased to the baseline level(P<0.05).There was no significant difference in the neutrophil and white blood cell counts between the glucocorticoid group and the non-glucocorticoid group on the 3rd day of GPT(P>0.05).The neutrophil and white blood cell counts in the 10-19 year old group on the 3rd day of GPT were significantly higher than those in the 20-29 year old group and the 40-49 year old group(P<0.05).Conclusion GPT can significantly increase neutrophil and white blood cell counts in uninfected patients,and the magnitude of the increase correlated with age but not with pre-GPT glucocorticoid usage.On the 1st day after GPT,the patients'neutrophil and white blood cell counts significantly decreased to the baseline level before GPT.
作者
曾雪霖
李薇
ZENG Xuelin;LI Wei(The Seventh Affiliated Hospital of Sun Yat-Sen University,Shenzhen,Guangdong,China 518107;Cancer Hospital Affiliated to Chongqing University,Chongqing,China 400030)
出处
《中国药业》
CAS
2024年第13期64-68,共5页
China Pharmaceuticals
基金
重庆市自然科学基金面上项目[cstc2020jcyj-msxmX0337]
重庆市沙坪坝区技术创新与应用发展项目[2023117]
中山大学附属第七医院2020-2022年度临床科研基金[ZSQYLCKYJJ202012]。
