摘要
目的:分析宫颈高危型人乳头瘤病毒(high risk human papilloma virus,HR-HPV)感染患者中医体质类型分布特点,为中医药调理体质防治宫颈HR-HPV感染提供依据。方法:选择2019年1月至2020年12月就诊于河南中医药大学第一附属医院妇科门诊及体检中心的420例宫颈HR-HPV感染者作为观察组,选择420例同时段宫颈HR-HPV检测阴性者为对照组。分析两组中医体质类型分布情况、观察组不同年龄段中医体质类型分布情况、观察组不同HR-HPV基因型别中医体质类型。结果:观察组中医体质分布依次为:痰湿质(30.50%)>湿热质(19.00%)>平和质(15.50%)>阳虚质(14.80%)>气虚质(10.00%)>阴虚质(5.90%)>瘀血质(2.70%)>气郁质(1.70%);对照组中医体质分布依次为:平和质(73.30%)>湿热质(8.40%)>阴虚质(5.70%)>痰湿质(4.50%)>气虚质(4.30%)>阳虚质/瘀血质(1.80%)>气郁质(0.20%)。两组中医体质类型比较,差异具有统计学意义(P<0.05),其中,痰湿质、湿热质、阳虚质、气虚质,两组间比较,差异具有统计学意义(P<0.001)。观察组体质类型居前三位的是痰湿质、湿热质、阳虚质,占全部体质类型的64.30%。对照组平和质324例,占比73.50%,观察组平和质81例,占比15.50%,两组间比较,差异具有统计学意义(P<0.001)。观察组中,痰湿质、阳虚质、阴虚质主要见于46~55岁,湿热质、气虚质、气郁质主要见于36~45岁,组间比较差异具有统计学意义(P<0.05)。两组宫颈HR-HPV16、18型和非16、18型中医体质比较,差异无统计学意义(P>0.05)。结论:痰湿质、湿热质、阳虚质为宫颈HR-HPV感染人群的易感体质;痰湿质、湿热质、阳虚质与年龄具有相关性,痰湿质多见于36~45岁,湿热质、阳虚质多见于46~55岁,HR-HPV基因型别与中医体质类型之间无明显相关性。
Objective:To observe the distribution of TCM constitution types in patients with high risk human papilloma virus(HR-HPV) infection in the cervix,and provide a basis for TCM to regulate constitution and prevent cervical HR-HPV infection.Methods:A total of 420 patients with cervical HR-HPV infection who visited the Obstetrics and Gynecology Clinic and Physical Examination Center of The First Affiliated Hospital of Henan University of CM from January 2019 to December 2020 were selected as the observation group,and 420 patients with negative cervical HR-HPV testing during the same period were selected as the control group.The distribution of TCM constitution types in two groups,the distribution of TCM constitution types in different age groups in the observation group,and the TCM constitution types in different HR-HPV gene types in the observation group were analyzed.Results:The distribution of TCM constitutions in the observation group were as follows:phlegm-dampness constitution(30.50%)>dampness-heat constitution(19.00%)> normal constitution(15.50%)>yang deficiency constitution(14.80%)>qi deficiency constitution(10.00%) >yin deficiency constitution(5.90%)>blood stasis constitution(2.70%)>qi depression constitution(1.70%).The distribution of TCM constitutions in the control group were as follows:normal constitution(73.30%) >dampness-heat constitution(8.40%)>yin deficiency constitution(5.70%)>phlegm-dampness constitution(4.50%) >qi deficiency constitution(4.30%)>yang deficiency constitution/blood stasis constitution(1.80%)>qi depression constitution(0.20%).The comparison between the two groups of TCM constitution types showed statistical significance(P<0.05).Among them,there was a significant difference(P<0.001) in phlegm-dampness constitution,dampness-heat constitution,yang deficiency constitution,and qi deficiency constitution between the two groups.The top three types of constitution in the observation group were phlegm-dampness constitution,dampness-heat constitution,and yang deficiency constitution,accounting for 64.30% of all constitution types.There were 324 cases of normal constitution in the control group,accounting for 73.50%,and 81 cases of normal constitution in the observation group,accounting for 15.50%.The difference between the two groups was statistically significant(P<0.001).In the observation group,phlegm-dampness constitution,yang deficiency constitution,and yin deficiency constitution were mainly seen at the age of 46-55,while dampness-heat constitution,qi deficiency constitution,and qi depression constitution were mainly seen at the age of 36-45.The difference between the groups was statistically significant(P<0.05).There was no statistically significant difference(P>0.05) between the two groups of cervical HR-HPV16,18 type and non 16,18 type TCM constitutions.Conclusion:Phlegm-dampness constitution,dampness-heat constitution,and yang deficiency constitution are susceptible constitutions of cervical HR-HPV infection population.Phlegm-dampness constitution,dampness-heat constitution,and yang deficiency constitution are correlated with age.Phlegm-dampness constitution is more common in 36 to 45 years old,while dampness-heat constitution and yang deficiency constitution are more common in 46 to 55 years old.There is no significant correlation between HR-HPV gene types and traditional Chinese medicine constitution types.
作者
李姗
张娥
张枫
范家英
LI Shan;ZHANG E;ZHANG Feng;FAN Jiaying(The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou,Henan,China,450000;The Second People′s Hospital of Henan Province,Zhengzhou,Henan,China,451191;Henan University of Chinese Medicine,Zhengzhou,Henan,China,450046)
出处
《河南中医》
2024年第7期1099-1104,共6页
Henan Traditional Chinese Medicine
基金
河南省中医药科学研究专项课题项目(2022JDZX054)。
关键词
高危型人乳头瘤病毒感染
中医体质
痰湿质
湿热质
阳虚质
阴虚质
平和质
气虚质
瘀血质
气郁质
high risk human papilloma virus infection
TCM constitution
phlegm-dampness constitution
dampness-heat constitution
yang deficiency constitution
yin deficiency constitution
normal constitution
qi deficiency constitution
blood stasis constitution
qi depression constitution
