摘要
目的:探讨叶酸联合维生素B_(12)(VB_(12))与二甲双胍治疗2型糖尿病(T2DM)患者的临床疗效。方法:选取2019年2月~2021年3月某院收治的112例T2DM患者作为研究对象,采用随机数字表法分为对照组(VB_(12)+二甲双胍,n=56)和观察组(叶酸+VB_(12)+二甲双胍,n=56)。对比两组患者血糖[空腹血糖(FBG)、餐后2h血糖(2hBG)]、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)、稳态模型胰岛素抵抗指数(HOMA-IR)和同型半胱氨酸(Hcy)水平以及Th1、Th17、Th1/Th17,并比较两组临床疗效、不良反应及并发症发生情况。结果:治疗后,两组患者FBG、2hBG、HO-MA-IR、HbA1c、FINS和Hcy均低于治疗前,且观察组低于对照组(P<0.05);Th1和Th17水平低于治疗前,且观察组低于对照组(P<0.05);Th1/Th17高于治疗前,且观察组高于对照组(P<0.05)。观察组临床治疗总有效率高于对照组(P<0.05);两组患者不良反应发生率比较无统计学差异(P>0.05);观察组的并发症发生率低于对照组(P<0.05)。结论:叶酸联合VB_(12)与二甲双胍治疗T2DM患者的疗效确切,可有效调节Th1/Th17平衡,改善血糖、胰岛素水平,安全性较高。
Objective:To investigate the therapeutic effect of folic acid combined with vitamin B_(12)(VB_(12))and metformin in patients with type 2 diabetes mellitus(T2DM).Methods:112 T2DM patients admitted to a certain hospital from February 2019 to March 2021 were selected as the study subjects.They were randomly divided into a control group(VB_(12)+metformin,n=56)and an observation group(folic acid+VB_(12)+metformin,n=56)using a random number table method.The blood glucose levels[fasting blood glucose(FBG),2-hour postprandial blood glucose(2hBG)],glycated hemoglobin(HbA1c),fasting insulin(FINS),homeostasis model assessment-insulin resistance(HOMA-IR),homocysteine(Hcy),as well as Th1,Th17,Th1/Th17 levels were compared between the two groups.And compare the clinical efficacy,adverse reactions,and incidence of complications between the two groups.Results:After treatment,the FBG,2hBG,HOMA-IR,HbA1c,FINS,and Hcy of both groups of patients were lower than before treatment,and were lower in the observation group than those in the control group(P<0.05);the levels of Th1 and Th17 were lower than before treatment,and were lower in the observation group was lower than those in the control group(P<0.05);Th1/Th17 was higher than before treatment,and was higher in the observation group was higher than that in the control group(P<0.05).The total effective rate of clinical treatment in the observation group was higher than that in the control group(P<0.05);there was no statistically significant difference in the incidence of adverse reactions between the two groups of patients(P>0.05);the incidence of complications in the observation group was lower than that in the control group(P<0.05).Conclusion:Combination of folic acid with VB_(12)and metformin has a definite therapeutic effect on T2DM patients,which can effectively regulate Th1/Th17 balance,improve blood glucose and insulin levels,and has high safety.
作者
王昱
张红瑾
姬劲锐
WANG Yu;ZHANG Hong-jin;JI Jin-rui(Department of General Medicine,Nanyang Central Hospital,Nanyang 473009,China;Department of Endocrinology,Nanyang Central Hospital,Nanyang 473009,China;People's Hospital of Zhengzhou,Zhengzhou 450000,China)
出处
《中国合理用药探索》
CAS
2024年第6期1-6,共6页
Chinese Journal of Rational Drug Use
基金
2019年度河南省医学科技攻关计划(联合共建)项目(LHGJ20191068)。
