摘要
肝纤维化是指各种病因导致反复或持续的肝脏实质细胞炎症、坏死,以及肝脏纤维结缔组织过度沉积的结果,是慢性肝病发展为肝硬化的必经阶段。抗病毒等病因治疗可一定程度减轻肝组织炎症,但无法完全终止肝纤维化进程。近年来研究发现,肝内巨噬细胞在肝纤维化的发生发展中发挥平衡炎症、调节免疫功能等重要作用,巨噬细胞的回输可延缓肝纤维化,其中M1/M2型巨噬细胞已成为探索巨噬细胞调节肝纤维化的关键。本文重点阐述肝内M1/M2型巨噬细胞在肝纤维化中的作用及其机制。
Hepatic fibrosis refers to repeated or persistent inflammation and necrosis of liver parenchymal cells and excessive deposition of liver fibrous connective tissue caused by various etiologies,which is a necessary stage for chronic liver disease to develop into cirrhosis.Etiological treatment as antiviral therapy can reduce the inflammation of the liver tissues to a certain degree,but cannot completely stop the process of liver fibrosis.In recent years,researchers have found that intrahepatic macrophages play an important role in the occurrence and progression of hepatic fibrosis,among which M1/M2 macrophages have become the key to exploring macrophages to regulate hepatic fibrosis.This article will focus on the role and mechanism of intrahepatic M1/M2 macrophages in hepatic fibrosis.
作者
杨钰萌
王新
麻婧
Yang Yu-Meng;Wang Xin;Ma Jing(Graduate Department,Xi'an Medical University,Xi'an,Shaanxi 710021,China;Department of Gastroenterology,the Second Affiliated Hospital(Tangdu Hospital),Air Force Military Medical University,Xi'an,Shaanxi 710032,China)
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2024年第6期726-732,共7页
Medical Journal of Chinese People's Liberation Army
基金
空军军医大学临床研究重点项目(2021LC2114)。
关键词
肝纤维化
巨噬细胞
细胞外基质
hepatic/liver fibrosis
macrophages
extracellular matrix