期刊文献+

M1/M2型巨噬细胞在肝纤维化中的作用研究进展

Research progress on the role of M1/M2 macrophages in hepatic fibrosis
下载PDF
导出
摘要 肝纤维化是指各种病因导致反复或持续的肝脏实质细胞炎症、坏死,以及肝脏纤维结缔组织过度沉积的结果,是慢性肝病发展为肝硬化的必经阶段。抗病毒等病因治疗可一定程度减轻肝组织炎症,但无法完全终止肝纤维化进程。近年来研究发现,肝内巨噬细胞在肝纤维化的发生发展中发挥平衡炎症、调节免疫功能等重要作用,巨噬细胞的回输可延缓肝纤维化,其中M1/M2型巨噬细胞已成为探索巨噬细胞调节肝纤维化的关键。本文重点阐述肝内M1/M2型巨噬细胞在肝纤维化中的作用及其机制。 Hepatic fibrosis refers to repeated or persistent inflammation and necrosis of liver parenchymal cells and excessive deposition of liver fibrous connective tissue caused by various etiologies,which is a necessary stage for chronic liver disease to develop into cirrhosis.Etiological treatment as antiviral therapy can reduce the inflammation of the liver tissues to a certain degree,but cannot completely stop the process of liver fibrosis.In recent years,researchers have found that intrahepatic macrophages play an important role in the occurrence and progression of hepatic fibrosis,among which M1/M2 macrophages have become the key to exploring macrophages to regulate hepatic fibrosis.This article will focus on the role and mechanism of intrahepatic M1/M2 macrophages in hepatic fibrosis.
作者 杨钰萌 王新 麻婧 Yang Yu-Meng;Wang Xin;Ma Jing(Graduate Department,Xi'an Medical University,Xi'an,Shaanxi 710021,China;Department of Gastroenterology,the Second Affiliated Hospital(Tangdu Hospital),Air Force Military Medical University,Xi'an,Shaanxi 710032,China)
出处 《解放军医学杂志》 CAS CSCD 北大核心 2024年第6期726-732,共7页 Medical Journal of Chinese People's Liberation Army
基金 空军军医大学临床研究重点项目(2021LC2114)。
关键词 肝纤维化 巨噬细胞 细胞外基质 hepatic/liver fibrosis macrophages extracellular matrix
  • 相关文献

参考文献10

二级参考文献59

  • 1赵志海,辛绍杰,赵景民,王松山,刘平,尹铁勇,周光德.MMP-2、MT-MMP-2在实验性肝纤维化形成和逆转过程中表达的动态研究[J].中华实验和临床病毒学杂志,2004,18(4):328-331. 被引量:4
  • 2冯国辉,雷志礼,宇鹏,宁新宇,姜伟,王甜甜,董兰,刘多辉,李军.乌司他丁对原位肝移植术患者中性粒细胞CD_(11b)/CD_(18)表达的影响[J].中华麻醉学杂志,2006,26(6):526-527. 被引量:5
  • 3WANG Gen-shu CHEN Gui-hua LU Min-qiang YANG Yang CAI Chang-jie YI Hui-min LI Hua XU Chi YI Shu-hong.Immunomodulatory therapy of cytomegalovirus pneumonia after liver transplantation[J].Chinese Medical Journal,2006(17):1430-1434. 被引量:8
  • 4Knittel T,Mehde M,Kobold D,et al. Expression patterns of matrix metalloproteinases and their inhibitors in parenchymal and non-parenchymal cells of rat liver: regulation by TNF-alpha and TGF-betal [J]. J Hepatol, 1999, 30(1) :48.
  • 5George J,Roulot D, Koteliansky VE, et al. In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type Ⅱ receptor: a potential new therapy for hepatic fibrosis[J]. Proc Natl Acad Sci USA,1999,96(22): 12719.
  • 6Murphy FR,Issa R,Zhou X,et al. Inhibition of apoptosis of activated hepatic stellate cells by TIMP-1 is mediated via effects on MMP inhibition:implications for reversibility of liver fibrosis[J]. J Biol Chem,2002,277(13) :11069.
  • 7Vaillant B,Chiaramonte MG,Cheever AW,et al. Regulation of hepatic fibrosis and extracellular matrix genes by the th response: new insight into the role of tissue inhibitors of matrix metalloproteinases[J]. J Immunol, 2001,167(12) :7017.
  • 8Lichtinghagen R,Huegel O,Seifert T,et al. Expression of matrix metalloproteinase-2 and -9 and their inhibitors in peripheral blood cells of patients with chronic hepatitis C[J]. Clin Chem,2000,46(2): 183.
  • 9Okazaki I,Watanabe T,Hozawa S,et al. Molecular mechanism of the reversibility of hepatic fibrosis: with special reference to the role of matrix metalloproteinases[J].JGastroenterol Hepatol, 2000,15 (Suppl): D26.
  • 10Arthur MJ, Fibrogenesis Ⅱ. Metalloproteinases and their inhibitors in liver fibrosis[J]. Am J Physiol Gastrointest Liver Physiol, 2000,279 (2): G245.

共引文献81

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部