摘要
目的:研究岩藻多糖对高脂饮食诱导小鼠肥胖和血脂代谢紊乱的影响。方法:将小鼠随机分为3组:对照组、高脂饮食组及岩藻多糖[100 mg/(kg·d)]处理组,每组6只。对照组喂食基础饲料,其余各组小鼠喂食高脂饲料,对照组、模型组给予生理盐水,岩藻多糖处理组给予岩藻多糖100 mg/(kg·d),每天灌胃1次,连续给药42 d。给药期间记录动物体重和摄食量;给药结束后计算小鼠脂体比,测定各组小鼠的血脂水平[甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和游离脂肪酸(FFA)]。结果:经岩藻多糖处理后可有效降低高脂饮食诱导的小鼠体重增加(P<0.01)和脂体比(P<0.05)。岩藻多糖灌胃后,对小鼠的摄食量无显著影响(P>0.05),但高脂饮食组能量摄入显著高于对照组(P<0.01),而岩藻多糖处理组小鼠摄食量和能量摄入量略低于高脂饮食组,但两组之间没有显著统计学意义(P>0.05)。岩藻多糖灌胃处理后,小鼠血清TG、TC、LDL-C和FFA水平较高脂饮食组呈现不同程度的下降趋势,HDL-C水平则显著升高。结论:岩藻多糖对高脂饮食诱导小鼠肥胖具有较强的预防作用,此外,还能预防高脂饮食引起的血脂代谢紊乱。
【Objective】To study the effect of fucoidan on obesity and lipid metabolism disorder induced by high-fat diet in mice.【Method】Mice were randomly divided into 3 groups including control group,high-fat diet group and fucoidan[100 mg/(kg·d)]treatment group,with 6 mice in each group.Mice in control group were fed basal diet,mice in other groups were fed high-fat diet,the mice in control group and high-fat diet group were given normal saline,the mice in fucoidan treatment group were given 100 mg/(kg·d)fucoidan,once a day by gavage,for 42 d continuously.The body weight and food intake of the animals were recorded during administration.At the end of administration,the fat-to-body ratio of mice was calculated,and the lipid levels[total triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)and free fatty acids(FFA)]were measured in each group.【Result】The treatment of fucoidan could effectively reduce the weight gain(P<0.01)and fat-to-body ratio(P<0.05)of mice induced by high-fat diet.There was no significant effect on the food intake of mice(P>0.05),but the energy intake of mice in high-fat diet group was significantly higher than that in control group(P<0.01),while the food intake and energy intake of mice in Fucoidan treatment group were slightly lower than those in high-fat diet group,there was no significant statistical significance between the two groups(P>0.05).The serum TG,TC,LDL-C and FFA levels of mice in the high fat diet group showed different degrees of decline,while the HDL-C level was significantly increased.【Conclusion】Fucoidan polysaccharide has a strong preventive effect on obesity induced by high-fat diet in mice,and can also prevent the disorder of lipid metabolism caused by high-fat diet.
作者
刘希鹏
孙娟
赵安达
刘喆
张海峰
唐雯
陈洁文
LIU Xi-peng;SUN Juan;ZHAO An-da;LIU Zhe;ZHANG Hai-feng;TANG Wen;CHEN Jie-wen(Department of Clinical Nutrition,Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 200011,China)
出处
《中国食物与营养》
2024年第6期56-60,共5页
Food and Nutrition in China
基金
上海市卫生和计划生育委员会科研课题青年项目(项目编号:20174Y0201)。
