摘要
目的:分析女性的体质量指数(BMI)是否影响胚胎倍性,并探讨其与整倍体胚胎移植临床结局的相关性。方法:共纳入随机分配至胚胎植入前非整倍体遗传学检测(PGT-A)组的606例不孕症女性,根据BMI将PGT-A患者分为4组:体重过低(<18.5 kg/m^(2),45例)、正常(18.5~24.9kg/m^(2),407例)、超重(25~29.9kg/m^(2),130例)和肥胖(≥30kg/m^(2),24例)。分析四组患者基于二代测序(NGS)技术的PGT-A检测结果、整倍体胚胎移植妊娠结局、新生儿结局及妊娠期并发症。结果:BMI<18.5kg/m^(2)、18.5~24.9 kg/m^(2)、25~29.9kg/m^(2)和≥30kg/m^(2)组的整倍体率分别为70.37%、69.63%、70.00%和69.44%,累积活产率分别为82.22%、77.39%、75.38%和75.00%,差异均无统计学意义(P>0.05)。调整潜在混杂因素后,各组间的胚胎倍性及临床结局各项指标比较,差异无统计学意义(P>0.05)。结论:在预后良好人群中,女性BMI与胚胎倍性和临床结局无明显相关性。
Objective:To analyze whether female body mass index(BMI)affects embryo ploidy to explore its association with clinical outcomes of euploid transfer.Methods:A total of 606 female infertile patients randomly assigned to the PGT-A group were included in this study and divided into four groups according to BMI:underweight(<18.5kg/m^(2),n=45),normal-weight(18.5~24.9kg/m^(2),n=407),overweight(25~29.9kg/m^(2),n=130),and obesity(≥30kg/m^(2),n=24).The results of PGT-A,pregnancy outcomes of euploid embryo transfer,neonatal outcomes and pregnancy complications based on next-generation sequencing(NGS)were analyzed.Result:The euploidy rates of BMI<18.5kg/m^(2),18.5~24.9kg/m^(2),25~29.9 kg/m^(2)and≤30kg/m^(2)groups were 70.37%,69.63%,70.00%and 69.44%,and the cumulative live birth rates were 82.22%,77.39%,75.38%and 75.00%,respectively,with no statistical difference(P>0.05).After adjusting for potential confounding factors,there was no significant difference in embryo ploidy and clinical outcome between the groups.Conclusions:In people with good prognosis,female BMI was not significantly associated with embryonic ploidy and clinical outcomes.
作者
李洁
赵晴
崔巍然
燕月月
周炜
倪天翔
张倩
颜军昊
Li Jie;Zhao Qing;Cui Weiran(Institute of Women,Children and Reproductive Health,Shandong University State Key Laboratory of Reproductive Medicine and Offspring Health Medical Integration and Practice Center,Shandong University,Jinan 250014)
出处
《现代妇产科进展》
2024年第7期481-487,共7页
Progress in Obstetrics and Gynecology
基金
国家重点研发计划(No:2021YFC2700604、No:2022YFC2703202)
山东省重点研发计划(No:2021LCZX02)
国家自然科学基金面上项目(No:82171648)
山东省青年专家泰山学者计划项目(No:tsqn201812154)
国家自然科学基金青年项目(No:82101752)
山东省自然科学基金青年项目(No:ZR2021QH075)
山东省自然科学基金面上项目(No:ZR2022MH087)。
