摘要
目的 分析研究2型糖尿病(T2DM)肾病患者甲状腺功能指标、血清白细胞介素6(IL-6)、白细胞介素10(IL-10)与肾功能的关系。方法 选取2021年4月至2023年8月黄山首康医院收治的T2DM肾病患者为T2DM肾病组(n=65),单纯T2DM患者为T2DM组(n=65)。比较两组血清甲状腺功能[促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)]、IL-6、IL-10与肾功能[血肌酐(Scr)、血尿素氮(BUN)、肾小球滤过率(eGFR)]水平。采用Pearson相关系数分析T2DM肾病患者TSH、FT3、FT4、IL-6、IL-10与Scr、BUN、eGFR的相关性。采用多因素Logistic回归分析T2DM肾病发生的影响因素,并绘制ROC曲线分析TSH、FT3、FT4、IL-6、IL-10水平对T2DM肾病发生的预测价值。结果 T2DM肾病组的TSH、IL-6、Scr、BUN水平均高于T2DM组(t=3.031、4.056、15.106、12.401,均P<0.05);T2DM肾病组的FT3、FT4、IL-10、eGFR水平均低于T2DM组(t=3.135、3.370、3.908、10.881,均P<0.05);Pearson相关系数分析显示,TSH、IL-6与Scr、BUN呈正相关,与eGFR呈负相关(均P<0.05);FT3、FT4、IL-10与Scr、BUN呈负相关,与eGFR呈正相关(均P<0.05)。多因素Logistic回归分析显示,年龄>60岁、病程>10年、TSH水平升高、FT3水平降低、FT4水平降低、IL-6水平升高及IL-10水平降低均是T2DM肾病发生的独立危险因素(P<0.05);ROC曲线分析显示,TSH、FT3、FT4、IL-6、IL-10水平及联合检测的曲线下面积(AUC)为0.832,联合检测优于单一检测(P<0.05)。结论 TSH、FT3、FT4、IL-6、IL-10水平与T2DM肾病患者肾功能相关,可能成为T2DM肾病发生的辅助预测指标。
Objective To analyze the relationship between thyroid function index,serum interleu-kin-6(IL-6),interleukin-10(IL-10)and renal function in patients with type 2 diabetes mellitus(T2DM)ne-phropathy.Methods Patients with T2DM nephropathy admitted to Huangshan Shoukang Hospital from April 2021 to August 2023 were retrospectively selected as the T2DM nephropathy group(n=65)and the T2DM pa-tients without nephropathy group(n=65).Serum thyroid function[thyroid stimulating hormone(TSH),free tri-iodothyronine(FT3),free thyroxine(FT4)],IL-6,IL-10 and renal function[serum creatinine(Scr),blood urea nitrogen(BUN),estimated glomerular filtration rate(eGFR)]were compared between the two groups.The Pearson correlation coefficient was used to analyze the correlation between TSH,FT3,FT4,IL-6,IL-10,Scr,BUN,and eGFR in T2DM nephropathy patients.Multivariate logistic regression was used to analyze the influencing factors of the occurrence of T2DM nephropathy,and a ROC curve was drawn to analyze the predic-tive value of TSH,FT3,FT4,IL-6 and IL-10 levels on the occurrence of T2DM nephropathy.Results The levels of TSH,IL-6,Scr,and BUN in the T2DM nephropathy group were higher than those in the T2DM group(t=3.031,4.056,15.106,12.401,P<0.05).FT3,FT4,IL-10,and eGFR levels in the T2DM nephropathy group were lower than those in the T2DM group(t=3.135,3.370,3.908,10.881,P<0.05).Pearson correlation coefficient analysis showed that TSH and IL-6 were positively correlated with Scr and BUN,but negatively corre-lated with eGFR(P<0.05).FT3,FT4,and IL-10 were negatively correlated with Scr and BUN,but positively correlated with eGFR(P<0.05).Multivariate logistic regression analysis showed that age>60 years,disease du-ration>10 years,increased TSH level increased,decreased FT3 level,decreased FT4 level,increased IL-6 level,and decreased IL-10 level were independent risk factors for T2DM nephropathy(P<0.05).ROC curve analysis showed that the levels of TSH,FT3,FT4,IL-6,and IL-10 and the area under the curve(AUC)of combined were 0.832,respectively.Combined detection was superior to single detection(P<0.05).Conclu-sion TSH,FT3,FT4,IL-6,and IL-10 levels are correlated with renal function in T2DM patients,and may serve as additional predictors of T2DM nephropathy.
作者
孙美秀
汪承武
江雪莲
朱德发
SUN Meixiu;WANG Chengwu;JIANG Xuelian;ZHU Defa(Department of Hematology and Endocrinology,Huangshan Shoukang Hospital,Huangshan,Anhui,China,245000;Department of Geriatrics,the First Affiliated Hospital of Anhui Medical University,Hefei,Anhui,China,230022)
出处
《分子诊断与治疗杂志》
2024年第6期997-1001,共5页
Journal of Molecular Diagnostics and Therapy
基金
国家自然科学基金项目(81272152)。
