摘要
目的 探讨盐酸戊乙奎醚联合氯解磷定治疗急性重度有机磷中毒(ASOPP)患者的疗效及对肾功能、血清降钙素原(PCT)、胆碱酯酶(CHE)、C反应蛋白(CRP)水平的影响。方法 采用随机数字表法将2018年1月至2023年1月皖南医学院附属太和医院收治的100例急性重度有机磷中毒患者分为观察组(n=50)和对照组(n=50)。两组均予以常规治疗,对照组予以氯解磷定,观察组予以盐酸戊乙奎醚和氯解磷定联合治疗,比较两组治疗效果、治疗前后肾功能[血清肌酐(Scr)、β2-微球蛋白(β2-MG)、胱抑素C(Cys-C)]、治疗前后CHE、PCT、CRP、不良反应情况。结果 治疗后,观察组CHE恢复时间以及住院时间短于对照组,治愈率高于对照组,差异有统计学意义(P<0.05);治疗后,观察组Scr、β2-MG、Cys-C、PCT、CRP水平均低于对照组,CHE高于对照组,差异有统计学意义(P<0.05);两组不良反应发生情况比较差异无统计学意义(P>0.05)。结论 盐酸戊乙奎醚联合氯解磷定治疗可提高ASOPP患者血清CHE活性,缩短治疗时间,改善肾功能、降低血清PCT、CRP水平,且不会增加不良反应。
Objective To explore the curative effect of penehyclidine hydrochloride combined with pralidoxime chloride and its influences on renal function,serum procalcitonin(PCT),cholinesterase(CHE)and C-reactive protein(CRP)in patients with acute severe organophosphorus pesticides poisoning(ASOPP).Methods According to the random number table method,100 patients with ASOPP were admitted to Taihe Hospital Affiliated with Wannan Medical College and were divided into an observation group(n=50)and a control group(n=50)between January 2018 and January 2023.The control group received routine treat-ment along with pralidoxime chloride,while the observation group received treatment with penehyclidine hydro-chloride in addition to pralidoxime chloride.The effectiveness of the treatment was compared between the two groups.Results After treatment,the recovery time of CHE and hospitalization time in the observation group were shorter than those in the control group.The cure rate was also higher in the observation group compared to the control group,and the difference was statistically significant(P<0.05).After treatment,levels of serum cre-atinine(Scr),β2-microglobulin(β2-MG),cystatin C(Cys-C),PCT,and CRP in the observation group were lower than those in control group.Conversely,CHE levels were higher in the observation group compared to the control group,with a statistically significant difference(P<0.05).There was no significant difference in the oc-currence of adverse reactions between the two groups(P>0.05).Conclusion Penehyclidine hydrochloride,when combined with pralidoxime chloride,can increase the activity of serum CHE,shorten treatment time,im-prove renal function,and reduce levels of serum PCT and CRP in ASOPP patients.These effects are achieved without increasing adverse reactions.
作者
孙杰
胡自廷
张清学
赵曙光
SUN Jie;HU Ziting;ZHANG Qingxue;ZHAO Shuguang(Department of Emergency Medicine,Taihe Hospital Affiliated to Wannan Medical College,Fuyang,Anhui,China,236600)
出处
《分子诊断与治疗杂志》
2024年第6期1152-1155,1160,共5页
Journal of Molecular Diagnostics and Therapy
基金
安徽省重点研究与开发计划项目(201904d11020045)。
