摘要
目的探讨司美格鲁肽(semaglutide)联合二甲双胍(metformin)治疗2型糖尿病(T2DM)的疗效,及其对机体免疫功能的影响。方法本研究纳入120例T2DM患者,将其随机分为观察组和对照组,各60例,分别给予司美格鲁肽联合二甲双胍治疗和二甲双胍口服治疗。在治疗12周后研究观察2组的临床疗效、体质量、体质量指数(BMI)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、三酰甘油(TG)水平以及C反应蛋白(CRP)和免疫球蛋白(IgA、IgG、IgM)水平;评估药物不良反应发生率。结果治疗12周后,2组总有效率具有显著差异(观察组vs对照组:95.0%vs 76.7%,P<0.05);治疗12周后,观察组的糖脂代谢指标(FBG、HbA1c、TC、TG)均得到明显改善,效果优于对照组(P<0.05)。治疗12周后,观察组的CRP和IgA水平降低、IgG和IgM水平提高,差异显著于对照组(P<0.05)。结论司美格鲁肽联合二甲双胍治疗T2DM在临床上表现出显著疗效,不仅改善了血糖控制,还对患者的免疫功能产生积极的影响。
Objective To explore the efficacy of semaglutide combined with metformin in the treatment of type 2 diabetes mellitus(T2DM)and its impact on the immune function of the body.Methods A total of 120 patients with T2DM were enrolled in this study and randomly divided into the observation group and the control group,with 60 cases in each group.The observation group received treatment with oral semaglutide combined with metformin,while the control group received treatment with oral metformin.Clinical efficacy,body weight,body mass index(BMI),and the levels of fasting blood glucose(FBG),glycosylated hemoglobin(HbAlc),total cholesterol(TC),triglycerides(TG),C-reactive protein(CRP)and immunoglobulin(IgA,IgG,IgM)were observed in both groups after 12 weeks of treatment,and the incidence of adverse drug reactions was assessed.Results After 12 weeks of treatment,there was statiscally significant difference in the total effective rate between two groups(the observation group vs the control group:95.0%vs 76.7%,P<0.05).After 12 weeks of treatment,compared with the control group,the observation group showed significant improvements in levels of glycolipid metabolism indicators(FBG,HbA1c,TC,TG)(P<0.05).After 12 weeks of treatment,in the observation group,CRP and IgA levels decreased,and IgG and IgM levels increased,and there was statiscally significant difference between the observation group and the control group(P<0.05).Conclusion Semaglutide combined with metformin in the treatment of T2DM has significant clinical efficacy.This therapy not only improves blood glucose control,but also has the positive impace on immune function of patients.
作者
肖洒
朱书瑶
李杰
于磊
XIAO Sa;ZHU Shuyao;LI Jie;YU Lei(Department of Clinical Pharmacy,West China Hospital,Sichuan University,Chengdu 610041,China)
出处
《长春中医药大学学报》
2024年第7期801-804,共4页
Journal of Changchun University of Chinese Medicine
基金
四川省科技计划项目(2020SZ0234)。
