摘要
目的探讨多囊卵巢综合征患者合并高雄激素血症的影响因素及高雄激素血症与凝血指标的关系。方法通过收集274例多囊卵巢综合征患者一般资料,测定内分泌相关指标(FSH、LH、AMH、雄激素)、代谢指标(空腹血糖、胰岛素)、凝血相关指标(FIB、PT、INR、PA、TT、APTT、D-Dimer、PLT),采用单因素分析及Logistics回归分析探讨多囊卵巢综合征患者合并高雄激素血症的影响因素,进一步分析高雄激素血症与凝血指标的可能关系。结果274例多囊卵巢综合征患者合并高雄激素血症比例为52.55%(144/274),非高雄激素血症比例为47.45%(130/274),两组在年龄、超重或肥胖分布比例及AMH、PT、INR、PA、TT、APTT水平差异无统计学意义(P>0.05),高雄激素血症组月经稀发、LH/FSH≥2.5、胰岛素抵抗分布比例及FIB、D-Dimer、PLT水平均高于非高雄激素血症组(P<0.05);Logistics回归分析结果提示,月经稀发、LH/FSH≥2.5、FIB是PCOS合并高雄激素血症的独立危险因素(OR值分别为2.286、3.105、1.615,P<0.05)。结论多囊卵巢综合征合并高雄激素血症的概率较高,与月经稀发、内分泌及凝血指标相关,高雄激素血症较非高雄激素血症患者具有更显著的高凝风险。
Objective To investigate the influence factors of hyperandrogenemia in patients with polycystic ovary syndrome(PCOS)and the relationship between hyperandrogenemia and coagulation index.Methods The general data of 274 patients with PCOS were collected,while multiple endocrine-related indexes(FSH,LH,AMH,androgen),metabolic indexes(fasting blood glucose,insulin),and coagulation-related indexes(FIB,PT,INR,PA,TT,APTT,D-Dimer,PLT)were measured.The influencing factors of hyperandrogenism in this study cohort were explored by univariate analysis and logistics regression analysis,and the potential relationship between hyperandrogenism and coagulation indexes was further analyzed.Results The proportion of 274 PCOS patients with hyperandrogenemia was 52.55%(144/274)and the proportion of non-hyperandrogenemia was 47.45%(130/274).There were no significant differences in age,distribution ratio of overweight or obesity and AMH,PT,INR,PA,TT and APTT between the two groups(P>0.05).Oligomenorrhea,LH/FSH≥2.5,distribution ratio of insulin resistance,FIB,D-Dimer and PLT in hyperandrogenemia group were significantly higher than those in non-hyperandrogenemia group(P<0.05).Logistics regression analysis suggested that oligomenorrhea,LH/FSH≥2.5 and FIB were independent risk factors for PCOS combined with hyperandrogenemia,with OR values of 2.286,3.105 and 1.615,respectively(P<0.05).Conclusion Polycystic ovary syndrome has a higher probability of hyperandrogenemia,which is related to oligomenorrhea,endocrine and coagulation indexes.Hyperandrogenemia has a higher risk of coagulation than non-hyperandrogenemia.
作者
韩倩
辛明蔚
李冠杉
何军琴
HAN Qian;XIN Mingwei;LI Guanshan;HE Junqin(Department of Traditional Chinese Medicine,Beijing Obstetrics and Gynecology Hospital,Capital Medical University/Beijing Maternal and Child Health Care Hospital,Beijing 100006,China;Department of Traditional Chinese Medicine,Beijing 100069,China)
出处
《标记免疫分析与临床》
CAS
2024年第6期1120-1124,共5页
Labeled Immunoassays and Clinical Medicine
基金
北京市中医药科技发展计划项目(编号:BJZYYB-2023-55)
首都医科大学附属北京妇产医院/北京妇幼保健院中青年学科骨干培养专项(编号:FCYY202103)
首都临床特色应用研究(编号:Z181100001718163)
北京妇幼保健院赵瑞华中医妇幼名医传承工作室(编号:2022-FYGZS-2)。
关键词
多囊卵巢综合征
高雄激素血症
凝血
影响因素
Polycystic ovary syndrome
Hyperandrogenemia
Blood clotting
Influencing factor
