摘要
目的探讨鸢尾素、瘦素水平对绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)的预测价值。方法收集2019年11月~2021年1月于广州中医药大学第三附属医院门诊就诊的64例绝经女性作为研究对象,分为骨质疏松组(n=33)和非骨质疏松组(n=31),比较两组受试者基线资料及鸢尾素、瘦素水平;采用Pearson相关性分析研究鸢尾素、瘦素水平与基线资料之间的相关性;采用受试者工作特征(receiver operating characteristic,ROC)曲线评价鸢尾素、瘦素对PMOP的预测效能。结果骨质疏松组的鸢尾素、瘦素水平均低于非骨质疏松组,差异有统计学意义(P<0.01);Pearson相关性分析结果显示,鸢尾素、瘦素水平与腰椎骨密度、整体骨密度均呈显著正相关(P<0.01);ROC曲线分析结果显示,鸢尾素的曲线下面积(area under the curve,AUC)为0.706,瘦素的AUC为0.702;并确定了两者的预测临界值:鸢尾素水平>224.88pg/ml,敏感度为58.06%,特异性为87.91%;瘦素水平>13.93μg/L,敏感度为61.29%,特异性为78.79%。结论鸢尾素、瘦素水平对PMOP具有良好的预测价值;绝经后女性血清鸢尾素水平<224.88pg/ml、瘦素水平<13.93μg/L,可能存在着骨量丢失的可能。
Objective To investigate the predictive value of irisin and leptin levels in postmenopausal osteoporosis(PMOP).Methods A total of 64 postmenopausal women treated in the outpatient department of the Third Affiliated Hospital of Guangzhou University of Chinese Medicine from November 2019 to January 2021 were collected as study subjects,and they were divided into osteoporosis group(n=33)and non-osteoporosis group(n=31).Baseline data and levels of irisin and leptin in the two groups were compared.Pearson correlation analysis was used to study the correlation between irisin,leptin levels and baseline data.The predictive efficacy of irisin and leptin levels in PMOP was evaluated by receiver operating characteristic(ROC)curve.Results The levels of irisin and leptin in osteoporosis group were lower than those in non-osteoporosis group,the difference was statistically significant(P<0.01);Pearson correlation analysis showed that irisin and leptin levels were positively correlated with lumbar bone density and overall bone density(P<0.01).ROC curve analysis showed that area under the curve(AUC)of irisin was 0.706,the AUC of leptin was 0.702;and the predictive critical value was determined:irisin level>224.88pg/ml,the sensitivity was 58.06%,the specificity was 87.91%;leptin level>13.93μg/L,the sensitivity was 61.29%,the specificity was 78.79%.Conclusion Irisin and leptin levels have good predictive value for PMOP.The serum irisin level<224.88pg/ml and leptin level<13.93μg/L in postmenopausal women may have the possibility of bone mass loss.
作者
杨志杰
林贤灿
吴建军
林适
杨彬彬
黄宏兴
YANG Zhijie;LIN Xiancan;WU Jianjun(The Third Clinical Medical School,Guangzhou University of Chinese Medicine,Guangdong 510006,China)
出处
《医学研究杂志》
2024年第6期40-43,10,共5页
Journal of Medical Research
基金
国家自然科学基金资助项目(面上项目)(81973886)
广东省研究生教育创新计划项目(2022XSLT013)。
