摘要
目的研究益气养阴化痰祛瘀法对甲状腺机能亢进症(Hyperthyroidism,简称甲亢)患者激素抗体和氧化应激因子表达的影响。方法选取2022年1月—2023年12月收治的76例甲亢患者,按照随机数字表法分组,对照组(38例)采用常规西药治疗,观察组(38例)在对照组基础上加用益气养阴化痰祛瘀方治疗;治疗2个月后对比两组临床疗效、中医证候积分、甲状腺功能(各项激素水平)、氧化应激因子、促甲状腺激素受体抗体(TRAb)、甲状腺过氧化物酶抗体(TPOAb)的表达。结果观察组治疗总有效率为94.74%(36/38),高于对照组(76.32%,29/38),差异有统计学意义(P<0.05)。治疗后,两组主症积分、次症积分和舌脉积分均降低,观察组低于对照组;两组促甲状腺激素(TSH)上升,游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)下降(P<0.05),观察组改善高于对照组;两组超氧化物歧化酶(SOD)升高,观察组SOD水平高于对照组,差异有统计学意义(P<0.05)。结论益气养阴化痰祛瘀法用于甲亢患者的治疗取得确切治疗成果,可以有效改善甲状腺功能,通过调控甲状腺激素水平、TRAb、TPOAb以及氧化应激因子的表达以改善病情,缓解症状。
Objective To study the nourishing Qi and Yin and resolving phlegm and blood stasis method on the expressions of hormone antibodies and oxidative stress factors in patients with hyperthyroidism.Methods A total of 76 cases of hyperthyroidism treated from January 2022 to December 2023 were selected to carry out the research.They were divided into two groups according to random number method.Thirty-eight cases in the control group were treated with conventional western medicine,and the other 38 cases in the observation group were treated with Yiqi Yangyin Huatan Quyu Formula(益气养阴化痰祛瘀方).After 3 months of treatment,the clinical efficacy,TCM syndrome scores,thyroid function(various hormone levels),the expressions of oxidative stress factor,thyroid stimulating hormone receptor antibody(TRAb)and thyroid peroxidase antibody(TPOAb)were compared between the two groups.Results The total effective rate of the observation group was 94.74%(36/38),which was higher than that of the control group(76.32%,29/38),and the difference was statistically significant(P<0.05).After treatment,the main symptom scores,secondary symptom scores and tongue and pulse scores of both groups were decreased,and the score of the observation group was lower than that of the control group.The levels of thyroid stimulating hormone(TSH)increased,and the levels of free triiodothyronine(FT3)and free thyroxine(FT4)in the two groups decreased(P<0.05).The improvement of the observation group was higher than that of the control group.The levels of superoxide dismutase(SOD)in two groups increased and the level in observation group was higher than that in the control group with statistical significance(P<0.05).Conclusion In the treatment of patients with hyperthyroidism,the therapy of nourishing Qi and Yin and resolving phlegm and blood stasis has achieved exact treatment results,effectively improving the thyroid function and the condition and relieving the symptoms by regulating the thyroid hormone levels and the expressions of TRAb and TPOAb.
作者
刘素荣
张新颖
李丽
黄延芹
LIU Surong;ZHANG Xinying;LI Li;HUANG Yanqin(Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong,China)
出处
《中华中医药学刊》
CAS
北大核心
2024年第7期35-38,共4页
Chinese Archives of Traditional Chinese Medicine
基金
国家中医药管理局全国名老中医药专家传承工作室项目(国中医药人教函[2022]75号)。
关键词
益气养阴化痰祛瘀法
甲亢
甲状腺功能
激素抗体
氧化应激因子
甲状腺过氧化物酶抗体
促甲状腺受体抗体
nourishing Qi and Yin and resolving phlegm and blood stasis method
hyperthyroidism
thyroid function
hormonal antibodies
oxidative stress factors
thyroid peroxidase antibody
thyrotropin receptor antibody
