摘要
骨代谢是指成骨细胞介导的骨形成和破骨细胞介导的骨吸收相偶联的动态过程, 对骨稳态的维持发挥关键作用。腺苷作为嘌呤能信号通路的重要组成部分, 具有抑制炎症、促进新生血管形成等多种作用, 并可影响成骨细胞的增殖和破骨细胞的分化。应用腺苷受体激动剂或载体靶向递送腺苷或可成为治疗骨质疏松症、骨折愈合不佳等临床问题的新手段。细胞外腺苷激活的嘌呤能信号通路已被证实作为调节骨组织功能及稳态的关键信号通路。本文就腺苷及其受体对生理骨代谢的调节及病理情况下与骨代谢病发生关系作一综述, 旨在为深入理解腺苷通路在骨代谢领域的重要临床意义提供参考及方向, 为骨代谢疾病的治疗提供新思路。
Bone metabolism refers to the dynamic process in which osteoblast-mediated bone formation and osteoclast-mediated bone resorption are coupled,playing a crucial role in maintaining bone homeostasis.Adenosine,as an important component of purinergic signaling pathway,has multiple effects such as inhibition of inflammation,promotion of neovascularization,and modulation of osteoblast proliferation and osteoclast differentiation.The application of adenosine receptor agonists or targeted delivery of adenosine may present a novel approach for addressing clinical challenges such as osteoporosis and poor fracture healing.The purinergic signaling pathway activated by extracellular adenosine has been identified as a key signaling pathway for regulating bone tissue function and homeostasis.This article reviews the regulation of physiological bone metabolism by adenosine and its receptors,as well as the relationship between adenosine and metabolic bone diseases in pathological conditions,aiming to provide reference and direction for understanding the significance of adenosine pathway in the field of bone metabolism,and offer new insights for the treatment of metabolic bone diseases.
作者
娄旭
章振林
岳华
Lou Xu;Zhang Zhenlin;Yue Hua(Shanghai Clinical Research Center of Bone Disease,Department of Osteoporosis and Bone Disease,Shanghai Sixth People′s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200233,China)
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2024年第5期450-454,共5页
Chinese Journal of Endocrinology and Metabolism
基金
国家重点研发计划(2021YFC2501701)
国家自然科学基金(82270932,81974126)。
关键词
腺苷
腺苷受体
骨代谢
Adenosine
Adenosine receptor
Bone metabolism
