摘要
目的:观察阿立哌唑联合利培酮治疗精神分裂症患者的效果。方法:选取2021年5月至2023年5月该院收治的100例精神分裂症患者进行前瞻性研究,按照抽签法将其分为对照组与观察组各50例。对照组予以利培酮治疗,观察组在对照组基础上联合阿立哌唑治疗,两组均治疗2个月。比较两组临床疗效,治疗前后精神症状[阳性与阴性症状量表(PANSS)]评分、认知功能[修订版韦氏记忆量表(WMS-RC)]评分,以及不良反应发生率。结果:观察组治疗总有效率为92.00%(46/50),高于对照组的74.00%(37/50),差异有统计学意义(P<0.05);治疗后,观察组阳性症状、阴性症状、一般精神病理学症状等PANSS评分均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组即刻记忆、延迟记忆、视觉记忆、延迟视觉记忆等WMS-RC评分均高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:阿立哌唑联合利培酮治疗精神分裂症患者可提高治疗总有效率和认知功能评分,降低精神症状评分,效果优于单纯利培酮治疗。
Objective:To observe the effect of Aripiprazole combined with Risperidone in the treatment of patients with schizophrenia.Methods:A prospective study was conducted on 100 patients with schizophrenia admitted to this hospital from May 2021 to May 2023.According to the lottery method,they were divided into control group and observation group,50 cases in each group.The control group was treated with Risperidone,while the observation group was treated with Aripiprazole on the basis of that of the control group.Both groups were treated for 2months.The clinical efficacy,the psychiatric symptoms [positive and negative symptom scale(PANSS)] score,the cognitive function [revised Wechsler memory scale(WMS-RC)] score,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the observation group was 92.00%(46/50),which was higher than 74.00%(37/50) of the control group,and the difference was statistically significant(P<0.05).After the treatment,the PANSS scores of positive symptoms,negative symptoms and general psychopathological symptoms in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the WMS-RC scores of immediate memory,delayed memory,visual memory and delayed visual memory in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Aripiprazole combined with Risperidone in the treatment of the patients with schizophrenia can improve the total effective rate and the cognitive function scores,and reduce the mental symptom scores.Moreover,it is superior to single Risperidone treatment.
作者
聂国进
NIE Guojin(Department of Psychiatry of Gao’an Hengxiang Psychiatric Hospital,Yichun 330811 Jiangxi,China)
出处
《中国民康医学》
2024年第13期95-97,共3页
Medical Journal of Chinese People’s Health
关键词
阿立哌唑
利培酮
精神分裂症
精神症状
认知功能
不良反应
Aripiprazole
Risperidone
Schizophrenia
Mental symptom
Cognitive function
Adverse reaction
