摘要
目的 比较载药微球与碘油肝动脉化疗栓塞术(TACE)治疗不可切除肝癌的临床效果。方法 将2020年10月至2023年10月收治的70例不可切除肝癌患者,均行TACE。根据TACE中使用栓塞剂的不同分为载药微球TACE(DEB-TACE)组(36例,栓塞剂使用CalliSpheres载药微球)和碘油TACE(c-TACE)组(34例,栓塞剂使用碘油)。于术后6个月比较2组临床疗效、肝功能指标[丙氨酸转氨酶(ALT)、总胆红素(TBiL)、谷草转氨酶(AST)]和并发症(呕吐、发热、中重度腹痛、急性肝功能障碍)发生率。结果 观察组疾病控制率高于对照组(88.89%比67.65%,P<0.05);2组术后ALT、TBiL、AST水平均高于术前(P<0.05),但DEB-TACE组ALT、AST、TBiL水平低于c-TACE组(P<0.001);2组各项并发症发生率比较差异无统计学意义(P>0.05)。结论DEB-TACE治疗不可切除肝癌患者效果优于c-TACE,且对肝功能影响更小,不会增加并发症的发生。
Objective To compare clinical efficacy of transarterial chemoembolization(TACE)with drug-loaded microspheres and TACE with iodine oil in the management of unresectable hepatocellular carcinoma.Methods A total of 70 patients with unresectable hepatocellular carcinoma admitted from October 2020 to October 2023 were subjected to TACE.According to the TACE embolic agent,they were divided into the drug-loaded microsphere TACE(DEB-TACE)group(36 patients,with CalliSpheres drug-loaded microspheres)and iodized oil TACE(c-TACE)group(34 patients,with iodized oil).Clinical outcomes,liver function indices[alanine aminotransferase(ALT),total bilirubin(TBiL),and glutamic transaminase(AST)]and the incidence of complications(vomiting,fever,moderate-to-severe abdominal pain,and acute hepatic dysfunction)were compared between the 2 groups at 6 months postoperatively.Results The DCR rate of the observation group was higher than that of the control group(88.89%vs 67.65%,P<0.05);the postoperative levels of ALT,TBiL,and AST were higher than those of the preoperative period in the two groups(P<0.05),but the levels of ALT,AST,and TBiL in the DEB-TACE group were lower than those in the c-TACE group(P<0.001);the differences in the complication rates of the 2 groups were not statistically significant(P>0.05).Conclusion DEB-TACE might be more effective than c-TACE in managing unresectable hepatocellular carcinoma,exerting less impact on liver functions without increasing complications.
作者
王明玉
WANG Ming-yu(Department of Gastroenterology and Oncology,the First People's Hospital of Linchuan District,Fuzhou,Fuzhou 344100,China)
出处
《实用临床医学（江西）》
CAS
2024年第3期14-17,共4页
Practical Clinical Medicine
关键词
不可切除肝癌
载药微球肝动脉化疗栓塞术
碘油肝动脉化疗栓塞术
unresectable hepatocellular carcinoma
transarterial chemoem bolization with drug-loaded microsphere
transarterial chemoem bolization with iodine oil
