摘要
目的:观察益气固本方联合穴位贴敷治疗脾气亏虚型原发免疫性血小板减少性紫癜(ITP)的疗效。方法:选取100例ITP患者,按随机数字表法分为观察组及对照组各50例,分别剔除2例,最终2组各48例。对照组接受重组人血小板生成素联合地塞米松治疗,观察组在对照组基础上加用益气固本方联合穴位贴敷治疗。2组连续治疗2周。比较2组短中期疗效、中医证候疗效,比较2组治疗前后中医症状积分及血小板计数(BPC)水平的变化。结果:2组短期、中期总有效率比较,差异无统计学意义(P>0.05)。治疗后,观察组中医证候总有效率为95.83%,对照组为72.92%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组慢性出血、体倦乏力、神疲懒言、食欲不振、食后腹胀中医症状积分均较治疗前下降(P<0.05),观察组上述5项中医症状积分均低于对照组(P<0.05)。随着治疗时间的延长,2组BPC水平均较治疗前升高,治疗后第14天、第30天、第60天、第90天,观察组BPC水平均高于对照组(P<0.05)。结论:益气固本方联合穴位贴敷能改善脾气亏虚型ITP患者中医证候,稳定血小板。
Objective:To observe the curative effect of Yiqi Guben Prescription combined with point application for immune thrombocytopenic purpura(ITP)of depletion of spleen-qi type.Methods:A total of 100 ITP patients were selected and divided into the observation group and the control group according to the random number table method,with 50 cases in each group.Two cases were excluded from each group,and 48 cases were included in each group.The control group received treatment with recombinant human thrombopoietin combined with Dexamethasone,and the observation group received treatment with Yiqi Guben Prescription combined with point application based on the treatment of the control group.Both groups were treated continuously for two weeks.The short-term and medium-term curative effects and traditional Chinese medicine(TCM)syndrome curative effects were compared between the two groups.The changes in TCM symptom scores and blood platelet count(BPC)levels were compared before and after treatment between two groups.Results:There was no significant difference in the total effective rates of short-term and medium-term curative effects between the two groups(P>0.05).After treatment,the total effective rate of TCM syndromes was 95.83%in the observation group,and 72.92%in the control group,the difference being significant(P<0.05).After treatment,the TCM symptom scores of chronic bleeding,fatigue and lack of energy,mental fatigue and laziness,poor appetite,and postprandial bloating in the two groups were decreased when compared with those before treatment(P<0.05);the above five TCM symptom scores in the observation group were lower than those in the control group(P<0.05).As the treatment time extended,the BPC levels in the two groups were increased when compared with those before treatment;on the fourteen,thirty,sixty,and ninety days after treatment,the BPC levels in the observation group were higher than those in the control group(P<0.05).Conclusion:Yiqi Guben Prescription combined with point application can improve the TCM syndrome of ITP patients of depletion of spleen-qi type and stabilize platelets.
作者
吕红姣
张蕾
张雪丽
LYU Hongjiao;ZHANG Lei;ZHANG Xueli(Quzhou People's Hospital,Quzhou Zhejiang 324000,China)
出处
《新中医》
CAS
2024年第11期182-186,共5页
New Chinese Medicine
关键词
免疫性血小板减少性紫癜
脾气亏虚型
益气固本方
穴位贴敷
糖皮质激素
血小板计数
Immune thrombocytopenic purpura
Depletion of spleen-qi type
Yiqi Guben Prescription
Point application
Glucocorticoid
Blood platelet count
