摘要
目的观察胃癌患者淋巴结转移、病情进展与四旋蛋白1重组蛋白(Tspan-1)表达水平的相关性,以便为临床治疗提供参考价值。方法选取福建省莆田市第一医院在2018年1月至2021年6收治的150例胃癌根治术患者作为研究对象,根据术后病理情况分为淋巴结转移组(LN组,n=120例)与无淋巴结转移组(NLN组,n=30例),采用问卷调查法收集两组一般资料,并对其进行logistic多因素分析和Pearson相关性分析,评估影响胃癌根治术后患者淋巴转移的相关危险因素及相关性情况。结果150例患者中共120例患者出现淋巴结转移,经调查可知,LN组严重疾病病情进展发生率高于NLN组(P<0.05);比较两组患者一般资料,NLN组肿瘤浸润深度、是否存在溃疡、肿瘤直径、肿瘤分型及年龄因素与LN组比较,差异有统计学意义(P<0.05);两组患者癌组织中Tspan-1蛋白表达水平均低于癌旁组织,且LN组癌组织中Tspan-1蛋白表达水平高于NLN组(P<0.05);logistic回归分析结果显示,肿瘤分型为未分化型、肿瘤浸润深度至浆膜层、存在溃疡与Tspan-1高表达均为胃癌患者淋巴结转移的独立危险因素(P<0.05);且经Pearson相关性分析可知,淋巴结转移、疾病进展分别与Tspan-1表达水平呈正相关(r>0,P<0.05)。结论导致胃癌根治术后患者淋巴结转移的主要影响因素为Tspan-1高表达水平,且还与患者术后病情进展风险高度相关。
Objective To observe the correlation between lymph node metastasis and disease progression and expression level of recombinant tetraspanin 1(Tspan-1)in patients with gastric cancer,so as to provide reference value for clinical treatment.Methods A total of 150 patients with gastric cancer who underwent radical gastrectomy in the First Hospital of Putian City from January 2018 to June 2021 were selected as the research objects,and were divided into the lymph node metastasis(LN)group(n=120 cases)and the no lymph node metastasis(NLN)group(n=30 cases)according to the pathological conditions after operation.The general data of the two groups were collected by questionnaire method,and logistic multivariate analysis and Pearson correlation analysis were used to evaluate the related risk factors and correlation of lymph node metastasis in patients with gastric cancer after radical gastrectomy.Results There were 120 patients with lymph node metastasis in the 150 patients.According to the investigation,the incidence of serious disease progression in the LN group was higher than that in the NLN group(P<0.05).General data of the two groups were compared.The depth of tumor invasion,whether there was ulcer,tumor diameter,tumor type and age in the NLN group were significantly different from those in the LN group(P<0.05).The expression level of Tspan-1 protein in cancer tissues of both groups was lower than that in adjacent tissues,and the expression level of Tspan-1 protein in cancer tissues of LN group was higher than that of NLN group(P<0.05).logistic regression analysis showed that undifferentiated tumor type,depth of tumor invasion to serosal layer,presence of ulcer and high expression of Tspan-1 were independent risk factors for lymph node metastasis in gastric cancer patients(P<0.05).Moreover,Pearson correlaton analysis showed that lymph node metastasis and disease progression were positively correlated with the expression level of Tspan-1,respectively(r>0,P<0.05).Conclusion The high expression level of Tspan-1 is the main influencing factor of lymph node metastasis in patients with gastric cancer after radical gastrectomy,and it is also highly related to the risk of disease progression after operation.
作者
蔡耀武
许雪峰
薛林云
赵志强
陈新铜
CAI Yaowu;XU Xuefeng;XUE Linyun;ZHAO Zhiqiang;CHEN Xintong(Department of Gastrointestinal Surgery,the First Hospital of Putian City,Fujian,Putian 351100,China;Department of Gastroenterology,the First Hospital of Putian City,Fujian,Putian 351100,China)
出处
《中国医药科学》
2024年第12期113-116,162,共5页
China Medicine And Pharmacy
基金
福建省卫生健康青年科研课题(2019-2-31)
福建省莆田市科技计划项目(2019SY003)。
