摘要
目的探讨健康体检人群内脏脂肪面积(VFA)与尿酸(UA)/高密度脂蛋白胆固醇(HDL-C)比值(UHR)的相关性。方法随机选取2020年6月至2022年6月于枣庄市立医院进行健康体检的人群360名。根据VFA值,将人群分为内脏脂肪型肥胖组(VFA≥100 cm^(2))172名和对照组(VFA<100 cm^(2))188名,比较两组一般资料及生化指标。采用Spearman相关分析评估VFA与UHR的相关性,多元线性回归分析UHR的影响因素;采用受试者工作特征(ROC)曲线评估UHR对内脏脂肪型肥胖的预测价值。结果与对照组相比,内脏脂肪型肥胖组体重指数(BMI)、VFA、皮下脂肪面积(SFA)、VFA/SFA(V/S)、甘油三酯(TG)、甘油三酯葡萄糖指数(TyG)、UA、UHR水平升高,HDL-C水平降低,差异有统计学意义(均P<0.05)。Spearman相关分析显示,UHR与BMI、VFA、SFA、V/S、TG、TyG呈正相关(P<0.01)。以UHR为因变量,BMI、VFA、SFA、V/S、TG、TyG为自变量进行多元线性回归分析,结果显示TG、VFA是UHR的影响因素。ROC曲线显示UHR预测内脏脂肪型肥胖的曲线下面积为0.741(P<0.001),最佳截断值为0.35。结论健康体检人群UHR与VFA有关,对内脏脂肪型肥胖有较好的预测价值。
Objective To investigate the correlation between visceral fat area(VFA)and uric acid(UA)/high density lipoprotein cholesterol ratio(HDL-C)ratio(UHR)in physical examination people.Methods A total of 360 physical examination people admitted to Zaozhuang Municipal Hospital from June 2020 to June 2022 were randomly selected,and they were divided into the visceral fat obesity group(n=172,VFA≥100 cm^(2))and the control group(n=188,VFA<100 cm^(2))according to the VFA value.The general data and biochemical indicators were compared.Spearman correlation analysis was used to evaluate the correlation between VFA and UHR,and multiple linear regression was used to analyze the UHR.The receiver operating characteristic(ROC)curves were used to evaluate the predictive value of UHR for visceral fat obesity.Results Compared with the control group,the visceral fat obesity group of body mass index(BMI),VFA,subcutaneous fat area(SFA),VFA/SFA(V/S),triglycerides(TG),triglyceride-glucose index(TyG),UA,and UHR levels increased,while HDL-C level decreased,all with statistically significant differences(all P<0.05).Spearman correlation analysis showed that UHR was positively correlated with BMI,VFA,SFA,V/S,TG and TyG(P<0.01).Taking UHR as the dependent variable,BMI,VFA,SFA,V/S,TG and TyG as the independent variables,multiple linear regression analysis showed that TG and VFA were the impacting factors of UHR.ROC curve showed that the area under the curve of UHR in predicting VFO was 0.741(P<0.001),and the best cutoff value was 0.35.Conclusion UHR in physical examination people is correlated to VFA,which has a good predictive value for visceral fat obesity.
作者
刘玉苓
吴高峰
王婷婷
费大东
LIU Yuling;WU Gaofeng;WANG Tingting;FEI Dadong(Department of Endocrine Metabolism,Zaozhuang Municipal Hospital,Shandong,Zaozhuang 277000,China)
出处
《中国医药科学》
2024年第12期126-129,共4页
China Medicine And Pharmacy
基金
济宁医学院教师科研扶持基金(JYFC2019FKJ206)。
