摘要
目的探讨慢性阻塞性肺疾病(慢阻肺)合并呼吸衰竭患者采用无创正压通气治疗对动脉血气参数、血清炎症因子水平的影响。方法选取60例慢阻肺合并呼吸衰竭患者作为研究对象,采用随机数字表法分为观察组(30例)和对照组(30例)。对照组予以常规方案治疗,观察组在对照组基础上予以无创正压通气治疗。比较两组患者治疗前后的动脉血气参数[血氧分压(PaO_(2))、血二氧化碳分压(PaCO_(2))、血氧饱和度(SaO_(2))]、心功能指标[左心室射血分数(LVEF)及血清肌钙蛋白I(cTnI)、N末端B型钠尿肽前体(NT-proBNP)]、血清炎症因子[血清C反应蛋白(CRP)、白细胞介素-6(IL-6)、转化生长因子-β_(1)(TGF-β_(1))]水平。结果与治疗前比较,治疗后两组PaO_(2)、SaO_(2)升高,PaCO_(2)降低,且观察组治疗后PaO_(2)(81.54±7.42)mm Hg(1 mm Hg=0.133 kPa)、SaO_(2)(93.53±6.22)%均高于对照组的(72.75±7.37)mm Hg、(85.17±5.76)%,PaCO_(2)(44.25±7.14)mm Hg低于对照组的(52.33±7.26)mm Hg(P<0.05)。与治疗前比较,治疗后两组LVEF均升高,血清cTnI、NT-proBNP水平均降低,且观察组治疗后LVEF高于对照组,cTnI、NT-proBNP水平均低于对照组(P<0.05)。与治疗前比较,两组治疗后血清CRP、IL-6、TGF-β_(1)水平均降低,且观察组治疗后血清CRP(8.68±2.14)mg/L、IL-6(14.66±3.44)pg/ml、TGF-β_(1)(99.43±12.63)ng/L均低于对照组的(23.41±3.69)mg/L、(30.28±5.17)pg/ml、(118.52±12.75)ng/L(P<0.05)。结论无创正压通气治疗慢阻肺合并呼吸衰竭可改善患者动脉血气和心功能,减轻炎症反应,进而可促进患者的病情恢复。
Objective To explore the effect of non-invasive positive pressure ventilation on arterial blood gas parameters and serum inflammatory factors in patients with chronic obstructive pulmonary disease complicated with respiratory failure.Methods 60 patients with chronic obstructive pulmonary disease complicated with respiratory failure were selected as the study subjects,and divided into an observation group(30 cases)and a control group(30 cases)according to random number table method.The control group was given conventional regimen,the observation group was given non-invasive positive pressure ventilation treatment based on the basis of the control group.Patients in both groups were compared in terms of arterial blood gas parameters[arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2)),and blood oxygen saturation(SaO_(2))],cardiac function indexes[left ventricular ejection fraction(LVEF)and cardiac troponin I(cTnI)N-terminal pro-B-type natriuretic peptide(NT proBNP)]and serum inflammatory factors[serum C-reactive protein(CRP),interleukin-6(IL-6),and transforming growth factor-β_(1)(TGF-β_(1))]before and after treatment.Results Compared with before treatment,PaO_(2) and SaO_(2) increased and PaCO_(2) decreased in the two groups after treatment;after treatment,the observation group had PaO_(2) of(81.54±7.42)mm Hg(1 mm Hg=0.133 kPa)and SaO_(2) of(93.53±6.22)%,which were higher than(72.75±7.37)mm Hg and(85.17±5.76)% in the control group;the observation group had lower PaCO_(2) of(44.25±7.14)mm Hg than(52.33±7.26)mm Hg in the control group(P<0.05).Compared with before treatment,LVEF increased in both groups after treatment,while serum cTnI and NT-proBNP levels decreased;after treatment,the observation group had higher LVEF than that in the control group,and lower cTnI and NT-proBNP levels than those in the control group(P<0.05).Compared with before treatment,the serum levels of CRP,IL-6 and TGF-β_(1) decreased in both groups after treatment;after treatment,the observation group had serum CRP of(8.68±2.14)mg/L,IL-6 of(14.66±3.44)pg/ml and TGF-β_(1) of(99.43±12.63)ng/L,which were lower than(23.41±3.69)mg/L,(30.28±5.17)pg/ml and(118.52±12.75)ng/L in the control group(P<0.05).Conclusion Non-invasive positive pressure ventilation can improve the arterial blood gas and cardiac function in patients with chronic obstructive pulmonary disease complicated with respiratory failure,and reduce inflammation,thus promoting the recovery of patients.
作者
刘静
LIU Jing(Department of Internal Medicine,Dingtao District Hospital of Traditional Chinese Medicine,Heze 274100,China)
出处
《中国现代药物应用》
2024年第13期44-47,共4页
Chinese Journal of Modern Drug Application
关键词
慢性阻塞性肺疾病
呼吸衰竭
无创正压通气
动脉血气参数
炎症因子
Chronic obstructive pulmonary disease
Respiratory failure
Non-invasive positive pressure ventilation
Arterial blood gas parameters
Inflammatory factors
