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中西医结合治疗肛门瘙痒症疗效的Meta分析

ta-analysis of Therapeutic Effect of Combined Traditional Chinese and Western Medicine on Anal Pruritus
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摘要 目的:运用Meta分析评价中西医结合治疗肛门瘙痒症的有效性、治愈率、复发率及不良反应。方法:以“肛门瘙痒症”“中西医结合”“随机对照试验”“pruritus ani”“combined traditional Chinese and Western medicine”“randomized controlled trail”为检索关键词,检索Pubmed、EMBASE、Cochrance library、中国临床试验注册中心、中国知网数据库(CNKI)、万方数据库、中国生物医学文献数据库(CBM)、维普全文数据库(VIP),检索时间为2013年1月至2023年6月,纳入文献为公开发表关于中西医结合治疗肛门瘙痒症的临床随机对照试验(RCT)文献,提取文献相关原始数据进行Meta分析。结果:共纳入143篇中文文献,经筛选后共纳入26篇。比较治疗组(中西医结合治疗)与对照组(单纯西医治疗)治疗肛门瘙痒症的疗效,总有效率(26篇)、治愈率(14篇)、复发率(3篇)、不良反应(8篇)研究的异质性分析结果具有同质性,合并效应量OR应用固定效应模型进行分析,OR分别为4.92(95%CI:3.81,6.36)、3.68(95%CI:2.93,4.64)、0.17(95%CI:0.07,0.38),差异均有统计学意义(P<0.05)。8篇报道不良反应的文献中治疗组均无不良发应发生,OR=0.32(95%CI:0.03,3.18),差异无统计学意义(P>0.05)。结论:中西医结合治疗肛门瘙痒症优于单纯西医治疗,能显著提高总有效率、治愈率,降低复发率,且不会增加不良发应。临床上应积极推广中西医结合治疗肛门瘙痒症。 Objective To evaluate the efficacy,cure rate,recurrence rate and adverse reactions of combined traditional Chinese and Western medicine in the treatment of anal pruritus by meta-analysis.MI ethodsChinese and Englishkey words of"肛门瘙痒症","中西医结合","随机对照试验","pruritus ani","combined traditional Chinese and Western medicine"and"randomized controlled trial"were searched in Pubmed,EMBASE,Cochrance library,China Clinical Trial Registry,China National Knowledge Network Database(CNKI),Wanfang Database,China Biomedical Literature Database(CBM)and VIP full-text database from January 2013 to June 2023.The included literatures were the published randomized controlled clinical trials(RCT)on the treatment of anal pruritus with combined traditional Chinese and Western medicine.The original data related to the literatures were extracted for meta-analysis.R I esultsA total of 143 Chinese literatures were included,and 26 were included after screening.The efficacy of the treatment group(combined traditional Chinese and Western medicine treatment)and the control group(simple Western medicine treatment)in the treatment of anal pruritus was compared.The heterogeneity analysis results of the total effective rate(26),cure rate(14),recurrence rate(3)and adverse reaction(8)studies were homogeneous,and the combined effect size OR was analyzed by using fixed effect model.OR was 4.92(95%CI:3.81,6.36),3.68(95%CI.2.93,4.64),0.17(95%CI:0.07,0.38),respectively,and the differences were statistically significant(P<0.05).There were no adverse events in the treatment group in the 8 literatures reporting adverse reactions,OR=0.32(95%CI:0.03,3.18),with no statistical significance(P>0.05).Conclusion The treatment of anal pruritus with combination of traditional Chinese and Western medicine is better than that with simple Western medicine,which can significantly improve the effective rate,cure rate,reduce recurrence rate,and will not increase adverse reactions.The combination of traditional Chinese and Western medicine should be promoted to treat anal pruritus.
作者 李冰涛 LI Bing-tao(Second Affiliated Hospital of Henan University of Science and Technology,Luoyang,Henan 471000)
出处 《中国肛肠病杂志》 2024年第5期19-26,共8页 Chinese Journal of Coloproctology
关键词 肛门瘙痒症 中西医结合 随机对照试验 META分析 Anal pruritus Combination of traditional Chinese and Western medicine Randomized controlled trial Meta-analysis
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