摘要
目的探讨甲状腺结节发生的因素及成人同型半胱氨酸(Hcy)与白球蛋白比值(AGR)、甲状腺自身抗体相关性。方法本文为回顾性研究,2019年10月至2020年8月有1427人在河北北方学院附属第二医院进行体检,通过简单随机抽样选取符合纳入排除标准受检者的临床资料进行分析,共计100例,均行甲状腺彩色超声,根据是否患有甲状腺结节分为对照组(未患甲状腺结节,n=52)和观察组(患甲状腺结节,n=48)。比较两组研究对象一般临床资料,分析成人同型半胱氨酸(Hcy)与白球蛋白比值(AGR)、甲状腺自身抗体[抗甲状腺球蛋白抗体(TGAb)与抗甲状腺过氧化物酶抗体(TPOAb)]相关性,用多因素非条件Logistic回归分析筛选出影响甲状腺结节发病率的相关因素。结果观察组性别、年龄、舒张压、收缩压、Hcy、AGR、TGAb及TPOAb与对照组比较,差异显著(P<0.05);以成人Hcy为因变量,采用Spearman对AGR、TGAb及TPOAb进行相关性分析,成人Hcy与AGR呈负相关(r=-0.384,P<0.05),TGAb、TPOAb呈正相关(r=0.218,0.224,P<0.05);以年龄、性别、舒张压、收缩压、Hcy、AGR、TGAb及TPOAb为自变量,甲状腺结节为因变量,对100例体检者进行多因素Logistic回归分析,分析显示,年龄≥40岁、女性是甲状腺结节发生的相关因素(P<0.05),Hcy、AGR、TGAb及TPOAb水平与甲状腺结节具有相关性(P<0.05)。结论甲状腺结节多发生于中年女性,Hcy、AGR、TGAb及TPOAb水平与其发生具有相关性,临床需针对以上指标定期进行甲状腺筛查工作。
Objective To investigate the factors involved in the development of thyroid nodules and the correlation between homocysteine(Hcy)and albumin-globulin ratio(AGR)and thyroid autoantibodies in adults.Methods As a retrospective study,a total of 1427 people who received physical examination at the Second Hospital Affiliated to Hebei North College from October 2019 to August 2020 and the clinical data of the subjects who fulfilled the criteria of NAR were selected for analysis by simple random sampling.All of subjects underwent thyroid color ultrasound scanning and were divided into a control group(without thyroid nodules,n=52)and an observation group(with thyroid nodules,n=48).The general clinical data of the two study groups were compared,and the correlation between Hcy and AGR and thyroid autoantibodies was analyzed.Confunding factors affecting the incidence of thyroid nodules were screened using multifactorial unconditional logistic regression analysis.Results The observation group showed statistically significant differences in gender,age,diastolic blood pressure,systolic blood pressure,Hcy,AGR,TGAb,and TPOAb as compared to the control group(P<0.05);Using adult Hcy as the dependent variable and Spearman′s correlation analysis of AGR,TGAb and TPOAb,adult Hcy was negatively correlated with AGR(r=-0.384,P<0.05)and TGAb and TPOAb were positively correlated(r=0.218,0.224,P<0.05);Using age,sex,diastolic blood pressure,systolic blood pressure,Hcy,AGR TGAb and TPOAb as independent variables and thyroid nodules as dependent variables,a multifactor logistic regression analysis was performed in 100 subjects who experienced physical check.The analysis showed that age≥40 years and female were relevant factors for the development of thyroid nodules factors(P<0.05),Hcy,AGR,TGAb and TPOAb were correlated with thyroid nodules(P<0.05).Conclusions Thyroid nodules are more common in middle-aged women,and there is a correlation between Hcy,AGR,TGAb,and TPOAb levels and thyroid nodules.Regular thyroid screening examination should be carried out based on the above indicators.
作者
李秀芬
孙太冉
冯云霞
牛丽丽
谢小谢
安阳
李鑫
LI Xiufen;SUN Taran;FENG Yunxia;NIU Lili;XIE Xiaoxie;AN Yang;LI Xin(Department of Endocrinology,the Second Affiliated Hospital of Hebei North University,Zhangjiakou 075100,China;Department of General Surgery,the Second Affiliated Hospital of Hebei North University,Zhangjiakou 075100,China;Nursing Department,the Second Affiliated Hospital of Hebei North University,Zhangjiakou 075100,China;Department of Critical Medicine,the Second Affiliated Hospital of Hebei North University,Zhangjiakou 075100,China;Department of Acupuncture and Moxibustion,the Second Affiliated Hospital of Hebei North University,Zhangjiakou 075100,China)
出处
《基础医学与临床》
CAS
2024年第8期1133-1136,共4页
Basic and Clinical Medicine
基金
张家口市重点研发计划项目(2021089D)。
