摘要
目的比较莪术油注射液与利巴韦林注射液治疗儿童病毒性下呼吸道感染的临床疗效和安全性。方法检索中国知网(CNKI)、万方数据库(Wanfang)、维普数据库(VIP)、中国生物医学文献数据库(CBM)、Cochrane Library、PubMed、Web of Science和Embase数据库,检索时限为各数据库建库至2023年12月,收集莪术油注射液与利巴韦林注射液治疗儿童下呼吸道感染的随机对照试验,采用Review Manager 5.3对纳入文献进行质量评价、数据整合分析。结果最终纳入8项临床研究,合计1096例患儿。Meta分析显示,同利巴韦林注射液比较,莪术油注射液治疗儿童病毒性下呼吸道感染可显著提升临床总有效率[OR=4.33,95%CI(2.57,7.27),P<0.001],显著缩短退热时间[MD=−1.02,95%CI(−1.36,−0.68),P<0.001],显著缩短咳嗽消失时间[MD=−1.97,95%CI(−2.31,−1.63),P<0.001],显著缩短肺部啰音消失时间[MD=−1.55,95%CI(−1.94,−1.16),P<0.001],显著缩短憋喘消失时间[MD=−1.25,95%CI(−1.65,−0.85),P<0.001]以及住院时间[MD=−2.04,95%CI(−3.25,−0.83),P=0.0009]。莪术油注射液的不良反应发生率与利巴韦林注射液比较无显著性差异[OR=0.18,95%CI(0.02,1.61),P=0.13]。所纳入的临床研究莪术油注射液组未见不良反应报道。结论莪术油注射液治疗儿童病毒性下呼吸道感染的临床疗效显著优于利巴韦林注射液,且临床用药安全。
Objective To compare the clinical efficacy and safety between Zedoary Turmeric Oil Injection(莪术油注射液)and Ribavirin Injection in the treatment of viral lower respiratory tract infections in children.Methods References China National Knowledge Infrastructure(CNKI),Wanfang Database(Wanfang),VIP Database,China Biomedical Literature Database(CBM),Cochrane Library,PubMed,Web of Science,and Embase Database were searched.The search period was from the establishment of each database until December 2023.Randomized controlled trials of Zedoary Turmeric Oil Injection and Ribavirin Injection in the treatment of viral lower respiratory tract infection in children were collected.Review Manager 5.3 was used to evaluate the quality of the included literatures and conduct data integration analysis.Results A total of eight studies were included,with a total of 1096 children.Meta-analysis showed that compared with Ribavirin Injection,Zedoary Turmeric Oil Injection in the treatment of viral lower respiratory tract infection in children could significantly improve the total clinical response rate[OR=4.33,95%CI(2.57,7.27),P<0.001];The duration of fever reduction was significantly shortened[MD=−1.02,95%CI(−1.36,−0.68),P<0.001];The duration of cough disappearance was significantly shortened[MD=−1.97,95%CI(−2.31,−1.63),P<0.001];The disappearance time of rales was significantly shortened[MD=−1.55,95%CI(−1.94,−1.16),P<0.001];The duration of asthmatic remission[MD=−1.25,95%CI(−1.65,−0.85),P<0.001],and the length of hospital stay[MD=−2.04,95%CI(−3.25,−0.83),P=0.0009]were significantly shortened.There was no significant difference in the incidence of adverse reactions between Zedoary Turmeric Oil Injection and Ribaverin Injection[OR=0.18,95%CI(0.02,1.61),P=0.13].No adverse reactions were reported in the Zedoary Turmeric Oil Injection group included in the clinical study.Conclusion Zedoary Turmeric Oil Injection had the better therapeutic effect on viral lower respiratory tract infection in children than Ribavirin Injection.The clinical use of Zedoary Turmeric Oil Injection was safe.
作者
袁飞龙
徐雨昳
姜程曦
YUAN Feilong;XU Yudie;JIANG Chengxi(School of Pharmacy,Wenzhou Medical University,Wenzhou 325000,China;Hefei Future Drug Development Co.,Ltd.,Hefei 230036,China)
出处
《中草药》
CAS
CSCD
北大核心
2024年第12期4132-4139,共8页
Chinese Traditional and Herbal Drugs
基金
合肥未来药物开发有限公司横向课题(KJHX2008)。
关键词
莪术油注射液
利巴韦林注射液
儿童病毒性下呼吸道感染
随机对照试验
META分析
Zedoary Turmeric Oil Injection
Ribavirin Injection
viral lower respiratory tract infection in children
randomized controlled trial
Meta-analysis
