摘要
目的:探究乳酸菌阴道胶囊联合甲硝唑阴道给药治疗萎缩性阴道炎效果。方法:回顾性分析2021年1月-2023年8月于本院门诊治疗的萎缩性阴道炎患者临床资料,随机从甲硝唑阴道给药治疗者中抽取73例纳入对照组,从甲硝唑联合乳酸菌阴道胶囊治疗者中抽取73例纳入观察组。比较两组治疗14 d后的临床疗效、乳酸杆菌阳性率;记录治疗前后的阴道菌群分布情况(乳酸菌、肠杆菌、白色念珠菌)、阴道微生态、阴道微循环(红细胞聚集率)、阴道炎症因子水平。结果:治疗14 d后,观察组疗效总有效率(90.4%)、乳酸杆菌阳性率(83.6%)均高于对照组(74.0%、68.5%),两组乳酸菌含量较治疗前升高且观察组(8.94±1.48 cfu/ml)高于对照组(7.35±1.26 cfu/ml),两组肠杆菌、白色念珠菌、红细胞聚集率、炎症因子水平较治疗前降低且观察组均低于对照组,观察组分泌物pH≤4.5(91.8%)、菌群密度为II~III级(87.7%)以及优势菌为乳酸菌(89.0%)比例均高于对照组(67.1%、71.2%、69.9%)(均P<0.05)。结论:甲硝唑联合乳酸菌阴道胶囊能帮助改善萎缩性阴道炎患者的阴道微生态及微循环。
Objective:To explore the effect of lactobacillus vaginal capsule combined with metronidazole vaginal administration for treating patients with atrophic vaginitis.Methods:The clinical data of the patients with atrophic vaginitis admitted to outpatient department for treatment from January 2021 to August 2023 were analyzed retrospectively.73patients were randomly selected from the patients who had accepted treatment of metronidazole vaginal administration in control group,and 73 patients were randomly selected from the patients who had accepted treatment of metronidazole combined with lactobacillus vaginal capsule in observation group.The clinical efficacy and the positive rate of lactobacillus after 14 days of treatment of the patients were compared between the two groups.The distribution status of the vaginal flora(lactobacillu,enterobacter and candida albicans),the vaginal microecology,the vaginal microcirculation(erythrocyte aggregation rate) and the vaginal inflammatory factors levels of the patients in the two groups before and after treatment were recorded.Results:After 14 days of treatment,the total effective rate(90.4%) and the positive rate of lactobacillus(83.6 %) of the patients in the observation group were significantly higher than those(74.0% and 68.5%) of the patients in the control group.The lactic acid bacteria content of the patients in the two groups after treatment had increased significantly,and which(8.94±1.48 cfu/ml) of the patients in the observation group was significantly higher than that(7.35±1.26 cfu/ml) of the patients in the control group.The aggregation rates of Enterobacter,Candida albicans and erythrocyte,and the inflammatory factors levels of the patients in the two groups after treatment had increased significantly,and which of the patients in the observation group were significantly lower than those of the patients in the control group.The proportions of the secretion pH≤4.5(91.8%),the flora density of grade Ⅱ-Ⅲ(87.7%) and the dominant bacteria of lactic acid bacteria(89.0%) of the patients in the observation group were significantly higher than those(67.1 %,71.2% and 69.9%) of the patients in the control group(all P<0.05).Conclusion:Metronidazole combined with lactobacillus vaginal capsule for treating the patients with atrophic vaginitis can help improve their vaginal microecology and microcirculation.
作者
胡琴
王静依
HU Qin;WANG Jingyi(The Second Affiliated Hospital of Chengdu Medical College,Nuclear Industry 416 Hospital,Chengdu,Sichuan Proince,610057)
出处
《中国计划生育学杂志》
2024年第7期1508-1512,1518,共6页
Chinese Journal of Family Planning
基金
四川省自然科学基金项目(2022NSFSC0776)。
关键词
萎缩性阴道炎
甲硝唑
乳酸菌阴道胶囊
阴道微生态
临床疗效
Atrophic vaginitis
Metronidazole
Lactobacillus vaginal capsule
Vaginal microecology
Clinical efficacy
