摘要
血管性痴呆(VD)作为一种由血管因素引起的严重认知障碍综合征,其表现为记忆、语言、推理以及执行功能的损伤,此外运动能力和自主神经功能也可能受到损害。目前,VD是国内外第2大痴呆类型,患病人群逐年增加,其加重了患者与家属的生活负担。VD的病变机制复杂,故本文从中医药抑制神经元细胞凋亡、抗氧化应激、增强突触可塑性、减轻髓鞘损伤等机制方面列举分析近5年来中医药(中药单体、中药复方、中成药、针刺、艾灸等)防治VD的靶点和分子机制的研究进展,以期为今后中医药治疗VD的临床研究和实验进展机制研究提供思路借鉴。
Vascular dementia(VD)is a severe cognitive impairment syndrome caused by vascular factors,which is characterized by impairments in memory,language,reasoning,and executive functions,in addition to motor and autonomic nervous functions.Currently,VD is the second largest type of dementia in China and abroad,and the number of people with the disease is increasing year by year,which increases the burden on patients and their families.The pathological mechanism of VD is complex.Therefore,this paper listed and analyzed the research progress on the targets and molecular mechanisms of traditional Chinese medicine(TCM)(single TCM,TCM compound,Chinese patent medicine,acupuncture,and moxibustion)in the prevention and treatment of VD in the past five years from the aspects of the mechanisms of inhibition of apoptosis of neuron cells,resistance to oxidative stress,enhancement of synaptic plasticity,and attenuation of myelin sheath damage,so as to provide ideas for future clinical research and experimental progress of the mechanism of TCM treatment of VD.
作者
姜晓璩
蔡静
吴远华
夏高富
陈锦秀
陈雨潇
JIANG Xiaoqu;CAI Jing;WU Yuanhua;XIA Gaofu;CHEN Jinxiu;CHEN Yuxiao(Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China;The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550001,China)
出处
《世界中医药》
CAS
北大核心
2024年第11期1680-1685,1692,共7页
World Chinese Medicine
基金
国家自然科学基金项目(82260970)
贵州省科技计划项目(黔科合基础-ZK[2022]一般519)
贵州中医药大学研究生教育创新计划自然科学项目(YCXZR2021008)。
关键词
血管性痴呆
中医药
基础实验
分子机制
作用靶点
研究进展
综述
病理机制
Vascular dementia
Traditional Chinese medicine
Basic experiments
Molecular mechanisms
Targets of action
Research progress
Review
Pathomechanism
