摘要
目的观察梅花针联合威伐光理疗+肌注腺苷钴胺对急性期带状疱疹(HZ)患者疼痛、免疫反应及血清神经降压素(NT)水平的影响。方法将140例急性期HZ患者按随机数字表法分为梅花针组与对照组。对照组采用威伐光理疗+肌注腺苷钴胺治疗,梅花针组在对照组基础上采用梅花针治疗。比较两组疗效、临床症状改善时间、免疫细胞数量、血清NT水平、视觉模拟量表(VAS)评分、是否遗留后遗神经痛(PHN)。结果梅花针组的临床总有效率为92.86%,高于对照组的80.00%(P<0.05);梅花针组患者止疱时间、结痂时间、疼痛开始缓解时间均短于对照组(P<0.05);治疗后,两组患者CD4+细胞百分比、CD4+/CD8+均上升,且梅花针组高于对照组;两组患者CD8+细胞百分比均下降,且梅花针组低于对照组(P<0.05);治疗1周后、治疗结束4周及治疗结束8周时,两组患者血清NT水平均上升,且同时间点梅花针组高于对照组(P<0.05);治疗1周后、治疗结束4周及治疗结束8周时,两组患者VAS评分均下降,且同时间点梅花针组低于对照组(P<0.05);梅花针组PHN的发生率低于对照组(P<0.05)。结论梅花针联合威伐光理疗+肌注腺苷钴胺治疗急性期HZ可有效缓解患者疼痛,提高免疫力,血清NT水平,临床症状改善效果显著。
Objective:To explore the effects of plum blossom needle combined with WIRA physical therapy and intramuscular injection of cobamamide on pain,immune response,and serum neurotensin(NT)level in pa⁃tients with acute herpes zoster(HZ).Methods:A total of 140 patients with acute phase HZ were randomly divid⁃ed into a needle group and a control medicine group according to random number table method.The control group was treated with WIRA physical therapy and intramuscular injection of cobamamide,while the needle group was treated with plum blossom needle therapy.The efficacy,clinical symptom improvement time,number of immune cells,serum NT level,Visual Analogue Scale(VAS)scores,and postherpetic neuralgia(PHN)were compared be⁃tween the two groups.Results:The total clinical effective rate of the needle group was 92.86%,which was higher than that of the western medicine group(80.00%)(P<0.05);the time for stopping blisters,scab formation time,and pain relief time in the needle group were lower than those in the control group(P<0.05);after treatment,the percentage of CD4+cells and CD4+/CD8+in both groups increased,and the needle group were higher than the control group;the percentage of CD8+cells in both groups decreased,and the needle group was lower than the con⁃trol group(P<0.05);at 1 week,4 weeks,and 8 weeks after treatment,the serum NT level in both groups in⁃creased,and at the same time point,the needle group was higher than the control group(P<0.05);at after 1 week,4 weeks,and 8 weeks after treatment,the VAS scores of both groups decreased,and at the same time point,the needle group was lower than the control group(P<0.05);the incidence of PHN in the needle group was lower than that in the control group(P<0.05).Conclusion:The combination of plum blossom needle with WIRA physical therapy and intramuscular injection of cobamamide in treating acute HZ can effectively alleviate pain,improve immunity,increase serum NT level,and obviously improve clinical symptoms.
作者
张丽娟
张翠
张乾
王向向
王丽
Zhang Lijuan;Zhang Cui;Zhang Qian;Wang Xiangxiang;Wang Li(Shijiazhuang Third Hospital,Hebei,Shijiazhuang 050000,China)
出处
《中国中医急症》
2024年第7期1244-1247,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
河北省中医药管理局2021年度中医药类科研计划课题(2021221)。
