摘要
目的观察升阳益胃汤加味治疗急性湿疹(湿热浸淫证)患者的临床疗效。方法将患者98例随机分为对照组与观察组各49例。对照组予复方氟米松软膏轻涂病灶局部。观察组加服升阳益胃汤加味治疗。两组病例连续观察2周。比较两组治疗效果、湿疹严重度湿疹面积与严重度指数(EASI)评分、瘙痒程度视觉模拟量表(VAS)评分、湿热浸淫证评分以及血清肿瘤坏死因子-α(TNF-α)、白细胞介素-4(IL-4)、白细胞介素-6(IL-6)水平。结果观察组总有效率为83.67%,高于对照组的67.35%(P<0.05)。两组EASI和VAS评分均降低,同时观察组降低更为显著(P<0.05)。治疗1周、2周后,两组病例湿热浸淫证评分明显下调,同时观察组病例在治疗后同时点下调更显著(P<0.05)。两组血清TNF-α、IL-4、IL-6水平明显下调,同时观察组病例下调更为显著(P<0.05)。结论升阳益胃汤加味治疗急性湿疹(湿热浸淫证)疗效显著,能有效控制病情,减轻瘙痒,改善中医证候,抑制炎症反应。
Objective:To observe the efficacy of Modified Shengyang Yiwei Decoction in the treatment of ecze⁃ma with syndrome of excessive dampness-heat.Methods:A total of 98 patients were randomly divided into the control group and observation group(49 cases in each group).The control group was lightly coated with compound flamethasone ointment.The conventional western medicine in the observation group was the same as that in the control group,and Modified Shengyang Yiwei Decoction was added for treatment.The two groups were observed continuously for 2 weeks.The therapeutic effect,eczema area and severity index(EASI)score,visual analog scale(VAS)score,syndrome of excessive dampness-heat score,and serum tumor necrosis factor(TNF)-α,interleukin(IL)-4,IL-6 levels were compared between the two groups.Results:The total effective rate of observation group was 83.67%,which was significantly higher than 67.35%of control group(P<0.05).After 2 weeks of treatment,the EASI and VAS scores were significantly reduced in two groups and reduced more significantly in observation group(P<0.05).After 1 week and 2 weeks of treatment,the syndrome of excessive dampness-heat score in the two groups was significantly reduced,and the simultaneous point in the observation group was more significantly decreased after treatment(P<0.05).After 2 weeks of treatment,serum levels of TNF-α,IL-4 and IL-6 in two groups were significantly reduced,and the reduction was more significant in observation group(P<0.05).Conclu⁃sion:Modified Shengyang Yiwei Decoction in the treatment of eczema with syndrome of excessive damp-heat has an evident effect,can effectively control the condition,relieve itching,improve traditional Chinese medicine syn⁃dromes,and inhibit inflammation.
作者
刘燕婷
吴迪
王占琴
武辉
Liu Yanting;Wu Di;Wang Zhanqin;Wu Hui(Shaanxi Hospital of Traditional Chinese Medicine,Shaanxi,Xi’an 710003,China)
出处
《中国中医急症》
2024年第7期1254-1256,共3页
Journal of Emergency in Traditional Chinese Medicine
基金
陕西省重点研发计划项目(2023-YBSF-457)。
