摘要
原发性干燥综合征(primary Sjogren's syndrome,pSS)作为风湿免疫科常见病,困扰着广大患者,不仅给患者带来身体和心理上的负担,长期的临床用药也造就了巨大的经济压力。TLR4/MyD88/NF-κB信号通路参与pSS的发生发展及治疗的多个环节。中医药在治疗pSS的过程中具有其优势,无论是单味药还是复方都在临床中效果显著。基于TLR4/MyD88/NF-κB信号通路探讨中医药治疗pSS机制对于中医药及临床诊治pSS具有重大意义。
Primary Sjögren’s syndrome(pSS)is a common disease in rheumatology and immunology,which troubles a large number of patients.It not only brings physical and psychological burdens to patients,but also creates huge economic pressures due to long-term clinical medication.The TLR4/MyD88/NF-κB signaling pathway is involved in the occurrence,development and treatment of pSS.Traditional Chinese medicine has its advantages in the treatment of pSS.Both single-flavor medicine and compound medicine have significant clinical effects.Exploring the mechanism of traditional Chinese medicine in treating pSS based on the TLR4/MyD88/NF-κB signaling pathway is of great significance to traditional Chinese medicine and clinical diagnosis and treatment of pSS.
作者
王丽文
万磊
李柯霏
闫佩文
张玉如
WANG Liwen;WAN Lei;LI Kefei;YAN Peiwen;ZHANG Yuru(Anhui University of Chinese Medicine,Anhui Hefei 230038,China;The First Affiliated Hospital of Anhui University of Chinese Medicine,Anhui Hefei 230031,China;Xin’an Medical and Modernization Research Institute,Anhui Hefei 230012,China)
出处
《中医药临床杂志》
2024年第7期1223-1226,共4页
Clinical Journal of Traditional Chinese Medicine
基金
国家自然基金面上项目(81973655)
国家自然基金面上项目(82274501)
新安医学教育部重点实验室(2020xayx04)。
