摘要
目的:观察季节变化对单胺类神经递质的影响,以探讨中医“天人相应”理论的生物学内涵。方法:将65例抑郁组患者以及40例正常组健康人纳入研究。比较四季5-羟色胺(5-HT)、去甲肾上腺素(NE)、多巴胺(DA)的水平。搜集四季气象资料,探讨上述四季单胺类神经递质分泌水平与气象因子的相关性。结果:正常组不同神经递质5-HT、DA、NE的四季整体分泌水平分别呈冬季<秋季<春季<夏季、秋季<冬季<夏季<春季、秋季<冬季<春季<夏季的趋势;抑郁组5-HT抑郁组四季分泌水平之间比较差异无统计学意义(P>0.05),抑郁组DA、NE的四季分泌趋势分别为春季<夏季<秋季<冬季、冬季<秋季<春季<夏季。其次,与正常组比较,四季的抑郁组5-HT、NE水平显著降低;春季、夏季的抑郁组DA水平显著降低,秋季、冬季的抑郁组DA水平显著升高。气象因子与单胺类神经递质的相关性主要体现在四季的日照时数、最低气压以及平均最高气温。结论:正常组和抑郁组的血清神经递质存在不同的季节性变化趋势,四季气象因子对人体情绪相关的单胺类神经递质的变化的影响,可能是“天人相应”理论的生物学基础之一。
Objective:To explore the biological connotation of the theory of correspondence between human and nature in traditional Chinese medicine based on seasonal changes in monoamine neurotransmitters.Methods:A total of 65 depression patients(depression group) and 40 healthy volunteers(normal group) were included in this study.The levels of 5-hydroxytryptamine(5-HT),norepinephrine(NE),and dopamine(DA) were compared among four seasons.The meteorological data of the four seasons were collected,and the correlations between the secretion levels of the above-mentioned monoamine neurotransmitters and the meteorological factors were evaluated.Results:In the normal group,the overall secretion levels of 5-HT,DA,and NE in four seasons showed the trends of winter(P>0.05),and the secretion levels of DA and NE followed the trends of spring<summer<autumn<winter and winter<autumn<spring<summer,respectively.Compared with the normal group,the depression group showed declined levels of 5-HT and NE in four seasons,lowered DA level in spring and summer,and elevated DA level in autumn and winter.The levels of monoamine neurotransmitters were mainly correlated with the sunshine duration,minimum air pressure,and average maximum temperature in four seasons.Conclusion:The serum levels of neurotransmitters in the normal group and the depression group had different seasonal trends.The influences of meteorological factors in four seasons on the changes of monoamine neurotransmitters associated with human emotion may be a biological basis of the theory of correspondence between human and nature.
作者
李文娜
王丽涛
谈博
孙一珂
林红
马淑然
LI Wenna;WANG Litao;TAN Bo;SUN Yike;LIN Hong;MA Shuran(The Third Affiliated Hospital of Beijing University of Chinese Medicine,Beijing 100020,China;Beijing University of Chinese Medicine,Beijing 100029,China;Peking University Sixth Hospital,Beijing 100191,China)
出处
《世界中医药》
CAS
北大核心
2024年第12期1826-1832,共7页
World Chinese Medicine
基金
国家自然科学基金面上项目(81774162)
国家自然科学基金面上项目(81774162)。
关键词
天人相应
神经递质
四季
气象因子
抑郁症
情志
日照时数
气压
气温
Correspondence between nature and human
Neurotransmitter
Four seasons
Meteorological factors
Depression
Emotion
Sunshine duration
Air pressure
Air temperature
