摘要
目的 观察布地奈德结合特布他林雾化吸入辅助治疗小儿肺炎支原体感染的临床效果。方法 选取2021年1月至2023年10月在青岛市即墨区大信卫生院治疗的78例肺炎支原体感染患儿作为研究对象,采取随机数字表法分为联合组与对照组,每组各39例。对照组采用常规用药治疗,联合组在对照组基础上采用布地奈德结合特布他林雾化吸入辅助治疗。比较两组临床疗效、肺功能指标、炎症指标、症状及体征消失时间、住院时间。结果 联合组临床总有效率高于对照组,差异有统计学意义(P <0.05)。治疗后,两组第1秒用力呼气容积、用力肺活量及一秒率均升高,且联合组高于对照组,差异有统计学意义(P <0.05)。两组C反应蛋白、肿瘤坏死因子-α、白细胞介素-6水平均降低,且联合组水平低于对照组,差异有统计学意义(P<0.05)。联合组发热、咳嗽、肺部湿啰音的消失时间及住院时间均短于对照组,差异有统计学意义(P <0.05)。结论 布地奈德结合特布他林雾化吸入对肺炎支原体感染患儿有良好的辅助治疗效果,可改善患儿肺功能,降低相关炎症指标水平,值得推广。
Objective To observe the clinical effect of Budesonide combined with Terbutaline nebulized inhalation in the adjunctive treatment of children with Mycoplasma pneumoniae infection.Methods A total of 78 children with Mycoplasma pneumoniae infection treated in Qingdao Jimo District Daxin Health Center from January 2021 to October 2023 were selected as the study objects.All the children were divided into the combination group and the control group by the random number table method,with 39 cases in each group.The control group received conventional medication treatment,and the combination group received adjuvant treatment with Budesonide combined with Terbutaline nebulized inhalation on the basis of the control group.The clinical efficacy,lung function indicators,inflammation indicators,disappearance time of symptoms and signs,and hospitalization time were compared between the two groups.Results The total clinical effective rate of the combination group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the forced expiratory volume in one second,forced vital capacity,and forced expiratory volume in one second/forced vital capacity in the two groups increased,and those in the combination group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of C-reactive protein,tumor necrosis factor-α,and interleukin-6 in the two groups decreased,and the levels in the combination group were lower than those in the control group,and the differences were statistically significant(P<0.05).The disappearance time of fever,cough,and lung moist rales,and hospitalization time in the combination group were shorter than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Budesonide combined with Terbutaline nebulized inhalation has a good adjuvant therapeutic effect in children with Mycoplasma pneumoniae infection,which can improve lung function and reduce the relevant inflammatory indicators,and is worthy of promotion.
作者
刘立清
金文刚
LIU Liqing;JIN Wengang(Qingdao Jimo District Daxin Health Center,Shandong Province,Qingdao 266229,China;Qingdao Jimo District Longshan Health Center,Shandong Province,Qingdao 266200,Ch ina)
出处
《妇儿健康导刊》
2024年第13期91-95,共5页
JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE
关键词
布地奈德
特布他林
雾化吸入
小儿肺炎支原体感染
Budesonide
Terbutaline
Nebulized inhalation
Children with Mycoplasma pneumoniae infection
