摘要
目的:探讨消化内镜局部给药联合抗幽门螺杆菌四联疗法治疗胃溃疡出血的效果。方法:选取2021年11月—2023年12月中国人民解放军联勤保障部队第980医院收治的胃溃疡出血患者74例作为研究对象,采用随机抽签法分为试验组和对照组,各37例。对照组采用抗幽门螺杆菌四联疗法治疗,试验组在对照组基础上给予消化内镜局部给药。比较两组治疗效果。结果:试验组腹痛、腹胀、食欲不振缓解时间,胃灼烧、反酸消失时间,Hp根除时间,溃疡愈合时间短于对照组,差异有统计学意义(P<0.05);治疗后,两组炎性细胞浸润、炎症活动性、腺体形态、腺体密度、黏膜厚度评分低于治疗前,试验组低于对照组,差异有统计学意义(P<0.05);治疗后,两组胃动素水平高于治疗前,胃泌素、胆囊收缩素水平低于治疗前,试验组优于对照组,差异有统计学意义(P<0.05);试验组不良反应发生率低于对照组,差异有统计学意义(P=0.041)。结论:消化内镜局部给药联合抗幽门螺杆菌四联疗法治疗胃溃疡出血的效果较好,可缓解患者疾病症状,减轻胃溃疡程度,调节胃肠激素水平,安全性较高。
Objective:To explore the effect of gastrointestinal endoscopic local drug administration combined with anti-Helicobacter pylori quadruple therapy in the treatment of gastric ulcer bleeding.Methods:Seventy-four patients with gastric ulcer hemorrhage admitted to the 980th Hospital of the Chinese People's Liberation Army Joint Logistic Support Force from November 2021 to December 2023 were selected as the study subjects,and were divided into the experimental group and the control group,each of which consisted of thirty-seven cases,using the method of random lot drawing.The control group was treated with anti-Helicobacter pylori quadruple therapy,and the experimental group was given local administration of digestive endoscopy on the basis of the control group.Compare the therapeutic effects of the two groups.Results:The time of relief of abdominal pain,abdomi-nal distension and loss of appetite,the time of disappearance of heartburn and acid reflux,the time of Hp eradication,and the time of ulcer healing of the experimental group were shorter than that of the control group,and the difference was statistically signifi-cant(P<0.05);after treatment,the scores of inflammatory cell infiltration,inflammatory activity,glandular morphology,glandular density,and mucosal thickness of the two groups were lower than those before treatment,and the experimental group was lower than the control group,and the difference was statistically significant(P<0.05);after treatment,the level of gastric actin was higher than that before treatment in both groups,and the level of gastrin and cholecystokinin was lower than that before treatment,and the experimental group was better than the control group,and the difference was statistically significant(P<0.05);the incidence rate of adverse reactions in the experimental group was lower than that in the control group,and the difference was statistically sig-nificant(P=0.041).Conclusion:Local administration of digestive endoscopy combined with anti-Helicobacter pylori quadruple therapy is more effective in the treatment of gastric ulcer bleeding,which can alleviate the symptoms of the patient's disease,re-duce the degree of gastric ulcer,regulate the level of gastrointestinal hormones,and has a higher degree of safety.
作者
张欢
Zhang Huan(The 980th Hospital of the Chinese People's Liberation Army Joint Logistic Support Force,Shijiazhuang 050000,Hebei Province,China)
出处
《中外医药研究》
2024年第18期57-59,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
胃溃疡出血
消化内镜
抗幽门螺杆菌四联疗法
胃肠激素
Gastric ulcer bleeding
Gastrointestinal endoscopy
Anti-Helicobacter pylori quadruple therapy
Gastrointestinal
