摘要
目的:分析亚临床甲状腺功能减退症患者血脂和Hcy水平及其与TSH的关系。方法:择取2020年3月至2023年3月于本院收治的亚临床甲减患者119例(亚临床甲减组)。另选取同期于本院体检,健康体检指标各项正常者121例为正常对照组。比较不同人群血脂代谢、Hcy、TSH水平。比较亚临床甲减组中亚1组、亚2组血脂代谢、Hcy水平。经偏相关系数、多元线性回归分析血脂代谢、Hcy水平与TSH水平的相关性。结果:亚临床甲减组TC、TG、LDL-C、Hcy、TSH水平均高于正常对照组(P<0.05)。亚临床甲减组、对照组HDL-C、FT3、FT4水平比较,差异无统计学意义(P>0.05)。亚2组TC、LDL-C、Hcy水平均高于亚1组(P<0.05)。亚2组、亚1组TG、HDL-C、FT3、FT4水平比较,差异无统计学意义(P>0.05)。校正性别、年龄、BMI、吸烟史、FPG及TSH因素,结果得知TSH是TC、TG、LDL-C、Hcy水平异常的危险因素,而TSH与HDL-C线性回归关系无统计学意义(P>0.05)。结论:亚临床甲减患者的血脂代谢和Hcy水平发生一定变化,且会受到TSH的影响,故应加强亚临床甲减患者的血脂代谢和Hcy水平监测,为临床医生提供了新的视角来评估和管理亚临床甲减患者的心血管风险。
Objective:To analyze the levels of blood lipids and homocysteine(Hcy)in patients with subclinical hypothyroidism(SCH)and their relationship with thyroid-stimulating hormone(TSH).Methods:A total of 119 patients diagnosed with SCH between March 2020 and March 2023 were selected as the SCH group.Additionally,121 healthy individuals with normal health examination indicators during the same period were selected as the normal control group.Blood lipid metabolism,Hcy,and TSH levels were compared between the SCH group and the normal control group.Within the SCH group,subgroup analysis(SCH1 and SCH2)based on TSH levels was conducted to compare lipid metabolism and Hcy levels.Correlation analysis using partial correlation coefficients and multiple linear regression were performed to assess the association between blood lipid metabolism,Hcy levels,and TSH levels.Results:Compared with the normal control group,the SCH group showed higher levels of total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),Hcy,and TSH(P<0.05).There were no statistically significant differences in high-density lipoprotein cholesterol(HDL-C),free triiodothyronine(FT3),and free thyroxine(FT4)levels between the SCH group and the normal control group(P>0.05).Subgroup analysis within the SCH group revealed that TC,LDL-C,and Hcy levels were higher in SCH2 compared to SCH1(P<0.05).There were no significant differences in TG,HDL-C,FT3,and FT4 levels between SCH1 and SCH2(P>0.05).After adjusting for gender,age,BMI,smoking history,fasting plasma glucose(FPG),and TSH,multiple linear regression analysis indicated that TSH was a risk factor for abnormalities in TC,TG,LDL-C,and Hcy levels,while the linear regression relationship between TSH and HDL-C was not statistically significant(P>0.05).Conclusion:Patients with subclinical hypothyroidism exhibit alterations in blood lipid metabolism and Hcy levels,which are influenced by TSH levels.Therefore,monitoring blood lipid metabolism and Hcy levels in patients with subclinical hypothyroidism should be strengthened.This study provides a new perspective for clinicians to assess and manage cardiovascular risks in patients with subclinical hypothyroidism.
作者
马望雯
赵燕萍
李文亚
MA Wangwen;ZHAO Yanping;LI Wenya(Suzhou Kowloon Hospital,School of Medical,Shanghai Jiaotong University,Jiangsu Suzhou 215028,China)
出处
《河北医学》
CAS
2024年第7期1130-1134,共5页
Hebei Medicine
基金
上海市2022年度“科技创新行动计划”自然科学基金项目,(编号:22ZR1412800)。
