摘要
目的研究使用人尿激肽原酶(HUK)联合阿替普酶(rt-PA)治疗急性脑梗死对患者神经功能和血管内皮功能的影响。方法选取2020年3月至2021年3月本院就诊急性脑梗死患者共84例,按暗箱摸球法法分为HUK组(n=42)和HUK+rt-PA组(n=42),两组均参照指南给予基础治疗,HUK组在此之上加用HUK治疗,HUK+rt-PA组在HUK组的基础上再加用rt-PA溶栓治疗,观察并分析HUK组和HUK+rt-PA组的治疗效果,于治疗前后观测HUK组和HUK+rt-PA组的神经功能、血管内皮功能变化,统计所有患者出现的不良反应。结果HUK+rt-PA组总有效率明显高于HUK组(P<0.05);在治疗后,HUK组和HUK+rt-PA组NIHSS评分、CSS评分出现显著降低,且后者低于前者,HUK组和HUK+rt-PA组ADL评分及血管内皮功能指标出现显著升高,且后者高于前者(P<0.05);HUK组和HUK+rt-PA组不良反应总发生率比较无差异(P>0.05)。结论对急性脑梗死患者采用HUK联合rt-PA治疗能促进神经功能复旧,血管内皮功能得以改观,且该疗法安全性良好,具有可推广性。
Objective To study the influence of human urinary kallidinogenase(HUK)combined with alteplase(rt-PA)on the neurological function and vascular endothelial function om patients with acute cerebral infarction.Methods 84 patients with acute cerebral infarction in the hospital were selected between March 2020 and March 2021 and were divided into HUK group(n=42)and HUK+rt-PA group(n=42)according to the dark box ball touching method.Both groups were given basic treatment in accordance with the guidelines,and the HUK group was additionally treated with HUK and the HUK+rt-PA group was additionally given rt-PA thrombolytic treatment on the basis of the HUK group.The therapeutic effects of HUK group and HUK+rt-PA group were observed and analyzed,and the changes in neurological function and vascular endothelial function were observed in HUK group and HUK+rt-PA group before and after treatment,and the adverse reactions were counted.Results The total effective rate in HUK+rt-PA group was significantly higher than that in HUK group(P<0.05).After treatment,the NIHSS score and CSS score in HUK group and HUK+rt-PA group were decreased significantly,and the scores were lower in HUK+rt-PA group than those in HUK group.The ADL score and vascular endothelial function indicators were obviously increased in HUK group and HUK+rt-PA group,and the above indicators in HUK+rt-PA group were higher compared to HUK group(P<0.05).There was no difference in the total incidence rate of adverse reactions between HUK group and HUK+rt-PA group(P>0.05).Conclusion HUK combined with rt-PA for patients with acute cerebral infarction can promote the recovery of nerve function and improve the vascular endothelial function in patients with acute cerebral infarction,and this therapy has good safety.
作者
吴变歌
WU Bian-ge(Dengfeng People’s Hospital,Dengfeng 452470,Henan Province,China)
出处
《罕少疾病杂志》
2024年第7期13-14,17,共3页
Journal of Rare and Uncommon Diseases
关键词
人尿激肽原酶
阿替普酶
急性脑梗死
神经功能
血管内皮功能
Human Urinary Kallidinogenase
Alteplase
Acute Cerebral Infarction
Neurological Function
Vascular Endothelial Function
