摘要
光催化氧化较传统氧化反应更具有安全可控、条件温和、绿色环保的优点,已成为化学前沿中的研究热点之一,并受到广泛关注。目前,受实验条件和设备的限制,光催化氧化反应在本科教学实验中较为缺乏。本实验利用实验室常规仪器组装出简易光反应装置,以高效低能的钠灯为光源催化氧化磷酸盐中间体,实现了1,2-二氧环乙烷类医用化学发光试剂的实验室微量化制备,丰富了光化学反应在实验教学中的应用。本实验使用的原料和试剂便宜易得,操作简便,产物收率高,实验既可实现单瓶独立操作,又可进行多瓶串联反应。本文综合考虑实验成本、实验与教学效率,以两瓶串联方式展开分组实验教学,在实现教学形式多样化的同时,培养学生合作意识,适合本科实验教学,帮助学生提高全面综合的实验操作能力,加深对自由基加成等反应机理的理解。
Photocatalytic oxidation,distinguished by its safety,controllability,mild conditions,and environmental friendliness compared to traditional oxidation reactions,has emerged as a prominent research focus in the forefront of chemistry,garnering widespread attention.However,its application in undergraduate teaching experiments has been limited by experimental conditions and equipment constraints.In this experiment,we devised a simple photoreaction device using conventional laboratory instruments.Employing a high-efficiency,low-energy sodium lamp as the light source to catalyze the oxidation of phosphate intermediates,we achieved the laboratory-scale synthesis of 1,2-dioxocycloethane-type medical chemiluminescence reagents,diversifying the application of photochemical reactions in experimental teaching.The materials and reagents used in this experiment are inexpensive and readily available,the operation is straightforward,and the yield of the product is high.The experiment allows for both independent single-bottle operations and the execution of multiple-bottle series reactions.Considering the experimental cost and teaching efficiency,we conducted group experimental teaching with a two-bottle series,fostering diverse teaching forms and nurturing students’cooperative skills.This approach is well-suited for undergraduate experimental teaching,aiding students in enhancing their comprehensive experimental operational abilities and deepening their understanding of reaction mechanisms such as radical coupling.
作者
马敏娜
欧阳玉瑾
邬源
袁明伟
杨丽娟
Minna Ma;Yujin Ouyang;Yuan Wu;Mingwei Yuan;Lijuan Yang(National and Local Joint Engineering Research Center for Green Preparation Technology of Bio-based Materials,College of Chemistry and Environment,Yunnan University for Nationalities,Kunming 650500,China)
出处
《大学化学》
CAS
2024年第5期134-143,共10页
University Chemistry
基金
国家自然科学基金项目(52163013)。
关键词
光催化氧化
安全可控
医用化学发光试剂
自由基加成
Photocatalytic oxidation
Safe and controllable
Medical chemiluminescence reagent
Radical coupling
