摘要
目的探讨门冬胰岛素治疗妊娠期糖尿病对患者胰岛素抵抗及妊娠结局的影响。方法选取2020年3月—2023年3月聊城市东昌府区妇幼保健院收治的140例妊娠期糖尿病患者为研究对象,参照随机数表法分为两组,各70例。对照组采取二甲双胍治疗,观察组采取门冬胰岛素治疗,比较两组血糖指标、胰岛素抵抗指标和妊娠结局。结果治疗后,观察组空腹血糖、餐后2 h血糖、糖化血红蛋白水平低于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组胰岛素抵抗指数低于对照组,胰岛β细胞功能指数高于对照组,差异有统计学意义(P均<0.05)。观察组不良妊娠结局发生率低于对照组,差异有统计学意义(P<0.05)。结论妊娠期糖尿病患者采取门冬胰岛素治疗可恢复正常水平,保护母婴健康。
Objective To investigate the influence of insulin aspart on insulin resistance and adverse pregnancy outcome in patients with gestational diabetes mellitus.Methods A total of 140 patients with gestational diabetes mellitus admitted to Dongchangfu Maternal and Child Health Hospital of Liaocheng from March 2020 to March 2023 were selected as the study objects,and they were divided into two groups with 70 cases each according to random number table method.Control group treated with metformin,observation group treated with aspartate insulin.The blood glucose and insulin resistance index and pregnancy outcome of two groups were compared.Results After treatment,the levels of fasting plasma glucose,2-hour postprandial plasma glucose and glycated hemoglobin A1c in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the insulin resistance index of the observation group was lower than that of the control group,and the isletβcell function index was higher than that of the control group,and the differences were statistically significant(both P<0.05).The incidence of adverse pregnancy outcome in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Aspartate insulin treatment for patients with gestational diabetes mellitus can restore normal levels and protect maternal and infant health.
作者
谢玉花
于倩倩
杨倩倩
闫伟
XIE Yuhua;YU Qianqian;YANG Qianqian;YAN Wei(Department of Gynecology,Dongchangfu District Maternal and Child Health Hospital,Liaocheng 252000,Shandong,China)
出处
《糖尿病新世界》
2024年第9期12-14,18,共4页
Diabetes New World Magazine
关键词
妊娠期糖尿病
门冬胰岛素
胰岛素抵抗
妊娠结局
Gestational diabetes mellitus
Aspartate insulin
Insulin resistance
Pregnancy outcome
