摘要
目的探讨肠易激综合征(irritable bowel syndrome,IBS)患者合并非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)的临床特征及危险因素。方法回顾性分析2020年6月至2023年6月于中国人民解放军总医院第六医学中心消化内科就诊的IBS患者,根据是否合并NAFLD将患者分为IBS-NAFLD组和IBS-非NAFLD组,比较两组患者的临床特征,包括一般临床资料、实验室检查结果和腹部症状,并用多因素Logistic回归分析筛选出IBS合并NAFLD的危险因素。结果共纳入145例IBS患者。其中IBS-NAFLD组78例(53.8%),IBS-非NAFLD组67例(46.2%)。多因素Logistic回归分析显示,年龄增长、BMI增加、高血压、TBA水平升高、TG水平升高、SIBO阳性是IBS合并NAFLD的独立危险因素。在腹部症状上,与IBS-非NAFLD组相比,IBS-NAFLD组的腹泻、腹胀、排气较多症状发生率显著增加(P<0.05)。两组出现口腔异味、食物过敏或不耐受、食欲不振、嗳气、消化不良、烧心反酸、腹痛、恶心、便秘、腹泻与便秘交替、里急后重、便腥臭且黏稠的比例差异均无统计学意义(P>0.05)。结论NAFLD在IBS患者中并不少见。年龄、BMI、血压、TBA水平、TG水平、SIBO是IBS患者合并NAFLD的独立危险因素。临床医师应重视对上述因素的控制,以减少IBS合并NAFLD风险的发生。
Objective To investigate the clinical characteristics and risk factors of irritable bowel syndrome(IBS)patients with non-alcoholic fatty liver disease(NAFLD).Methods A retrospective analysis was conducted on IBS patients who visited the Department of Gastroenterology at the Sixth Medical Center of Chinese PLA General Hospital from Jun.2020 to Jun.2023.The patients were divided into IBS-NAFLD group and IBS-non-NAFLD group,based on whether they had NAFLD.The clinical characteristics of the two groups were compared,including genereral clinical data,laboratory test results and abdominal symptoms.Multivariable Logistic regression analysis was used to identify the risk factors for IBS patients with NAFLD.Results Among 145 patients with IBS,78(53.8%)were NAFLD while 67(46.2%)were not.Multivariable Logistic regression analysis showed that age,BMI,hypertension,TBA,TG,SIBO were independent risk factors for IBS patients combined with NAFLD.In terms of abdominal symptoms,the incidence of diarrhea,bloating,and more exhaustion was significantly higher in patients with NAFLD than that in patients without NAFLD(P<0.05).There was no significant difference in the occurrence of bad breath,food allergy or intolerance,loss of appetite,belching,dyspepsia,worry and acid reflux,abdominal pain,nausea,constipation,alternating diarrhoea and constipation,tenesmus,and smelly and sticky stools(P>0.05).Conclusions NAFLD is not rare in IBS patients.Age,BMI,hypertension,TBA,TG,SIBO were independent risk factors for IBS patients with NAFLD.Clinical physicians should pay attention to controlling the above factors to reduce the incidence of IBS patients combined with NAFLD.
作者
冼锐
董昌昊
王广祥
刘茜
李超
崔立红
XIAN Rui;DONG Changhao;WANG Guangxiang;LIU Qian;LI Chao;CUI Lihong(School of Medicine,South China University of Technology,Guangzhou 510006;Department of Gastroenterology,the Sixth Medical Center of Chinese PLA General Hospital,China)
出处
《胃肠病学和肝病学杂志》
CAS
2024年第6期727-731,739,共6页
Chinese Journal of Gastroenterology and Hepatology
基金
国家自然科学基金(82070553)
首都卫生发展科研专项(首发2020-2-5113)。
关键词
肠易激综合征
非酒精性脂肪性肝病
小肠细菌过度生长
Irritable bowel syndrome
Non-alcoholic fatty liver disease
Small intestinal bacterial overgrowth
