摘要
免疫治疗已成为当今医学解决重大疑难疾病的突破口之一,但其面临的挑战仍然不少。当前,中医学的阴火理论受到广泛关注,被应用于多种疾病的治疗中,其机制与调节机体的免疫状态密切相关。本文在系统回顾中医药免疫调节研究进展的基础上,以挖掘阴火理论的科学内涵为切入点,讨论阴火理论下指导中西医结合免疫治疗的可能性和新思路。多种中药单体、有效部位或者复方免疫促进、免疫抑制或者双向调节作用,在免疫调节中展现了巨大的潜力。阴火理论与免疫调节的关联密切,阴火的产生与免疫异常、慢性炎症、代谢异常、应激等密切相关,临床运用阴火理论治疗相关疾病能够有效调节免疫功能,降低炎症水平。阴火理论是深入传承中医药原创理论精华,有效对接西医免疫相关理论的范例,但仍需开展相关系统生物学研究,进一步升华中医药理论和实践经验,从而发挥中医药的特色优势,解决重大疑难疾病防治中的免疫失调难题,赋予生命科学新内涵,推动临床应用、验证和创新发展。
Immunotherapy has become one of the breakthroughs in solving major and difficult diseases in modern medicine,but it still faces many challenges.Yin fire theory in traditional Chinese medicine has received widespread attention and has been applied to the treatment of multiple diseases,and its mechanism is closely related to the regulation of the immune state of the body.Based on a systematic review of the progress in the study of immune regulation of traditional Chinese medicine,this paper discusses the possibility and new ideas of the combination of traditional Chinese and western medicine immunotherapy guided by the Yin fire theory,taking the scientific connotation of the theory of Yin fire as the starting point.A variety of traditional Chinese medicine monomers,effective parts or compounds have shown great potential in immune regulation by promoting,immunosuppressing or two-way regulation.Yin fire theory is closely related to immune regulation,and the generation of Yin fire is closely related to immune abnormalities,chronic inflammation,metabolic abnormalities,stress,etc.Clinical application of Yin fire theory to treat related diseases can effectively regulate immune function and reduce the level of inflammation.Yin fire theory is an example of deeply inheriting the essence of the original theory of traditional Chinese medicine and effectively docking with western medicine immune related theories,but it still needs to carry out relevant system biology research to further sublimate the theory and practical experience of traditional Chinese medicine,so that the manifestation of the characteristic advantages of traditional Chinese medicine will certainly give new meaning to life science and promote clinical application,verification and innovative development.
作者
胡镜清
童宏选
刘德培
Jingqing Hu;Hongxuan Tong;Depei Liu(Institute of Basic Theory for Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700;State Key Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences,Beijing 100005)
出处
《中国科学基金》
CSSCI
CSCD
北大核心
2024年第3期512-516,共5页
Bulletin of National Natural Science Foundation of China
基金
国家自然科学基金项目(82074316)
国家重点研发计划项目(2019YFC1708501)的资助。
关键词
阴火
中西医结合
免疫调节
慢性炎症
Yin fire theory
combination of Chinese eand Western Medicine
immunomodulation
chronic inflammation
