摘要
目的探究甲功五项联合甲状腺过氧化物酶自身抗体(TPOAb)及抗甲状腺球蛋白抗体(TGAb)诊断甲状腺功能减退(简称甲减)的临床价值。方法将2022年10月至2023年10月在甘肃省天水市第一人民医院进行检查的108例甲减患者纳入研究组,于同期随机挑选108例健康体检人员作为对照组。两组均进行甲功五项、TPOAb、TGAb检测,分析甲功五项与TPOAb、TGAb联合检验诊断甲减的临床效能。结果与对照组比,研究组血清三碘甲状腺原氨酸(T_(3))、四碘甲腺原氨酸(T_(4))、游离三碘甲状腺原氨酸(FT_(3))、游离四碘甲腺原氨酸(FT_(4))水平更低,促甲状腺激素(TSH)、TPOAb、TGAb水平更高,P<0.05;甲功五项与TPOAb、TGAb联合检验诊断甲减的灵敏度、特异度、准确率均高于单一指标检验,P<0.05。结论甲功五项与TPOAb、TGAb联合检验可提高甲减诊断准确率,为后续治疗提供参考。
Objective:To explore the clinical value of the five items of thyroid function combined with thyroid peroxidase autoantibodies(TPOAb)and anti-thyroglobulin antibodies(TGAb)in the diagnosis of hypothyroidism.Methods:108 patients with hypothyroidism who were examined in the First People's Hospital of Tianshui City,Gansu Province from October 2022 to October 2023 were included in the study group,and 108 healthy medical examiners were randomly selected as the control group during the same period.The five items of hypothyroidism,TPOAb and TGAb were tested in both groups,and the clinical efficacy of the five items of hypothyroidism combined with TPOAb and TGAb was analyzed.Results:Compared with the control group,the levels of serum triiodothyronine(T_(3))、tetraiodothyronine(T_(4))、free triiodothyronine(FT_(3))and free tetraiodothyronine(FT_(4))in the study group were lower,while the levels of thyroid stimulating hormone(TSH)、TPOAb and TGAb were higher,P<0.05.The sensitivity,specificity and accuracy of the combined test of the five items of A-Gong,TPOAb and TGAb in diagnosing hypothyroidism were higher than those of the single index test,P<0.05.Conclusion:The combined test of five items of hypothyroidism,TPOAb and TGAb can improve the diagnostic accuracy of hypothyroidism and provide reference for followup treatment.
作者
马青川
Ma Qingchuan(First People's Hospital of Tianshui City Gansu Province,Tianshui Gansu 741099,China)
出处
《生命科学仪器》
2024年第2期76-78,共3页
Life Science Instruments
