摘要
精神分裂症(schizophrenia,SZ)是常见的慢性精神疾病,其核心症状之一是认知功能障碍,抗精神病药物治疗在改善认知功能方面效果不佳。近期研究发现,二甲双胍可改善SZ患者的认知功能障碍,其机制可能包括改善胰岛素抵抗、修复神经损伤、调节神经免疫和抗氧化应激。阐明这些机制可为SZ认知功能障碍的治疗提供新思路。
Schizophrenia is a common chronic mental disorder.Cognitive dysfunction is one of its core symptoms,which severely affects the social functioning of patients.Currently,antipsychotic medication treatments have poor efficacy in improving cognitive functions.Recent studies have found that metformin can improve cognitive dysfunction in patients with schizophrenia.However,the mechanism of action remains unclear.This review summarizes the therapeutic effects of metformin on cognitive dysfunction in schizophrenia patients such as improving insulin resistance,repairing neuronal damage,regulating neuroimmunity,and combating oxidative stress,thereby providing new insights for the treatment of cognitive dysfunction in schizophrenia.
作者
朱厚名
崔翠翠
夏伟丽
季加翠
张洪昌
苏现彪
王忠宝
马家树
褚昊冉
郑云哨
白录东
李然然
ZHU Houming;CUI Cuicui;XIA Weili;JI Jiacui;ZHANG Hongchang;SU Xianbiao;WANG Zhongbao;MA Jiashu;CHU Haoran;ZHENG Yunshao;BAI Ludong;LI Ranran(Shandong Mental Health Center(Shandong University Affiliated Mental Health Center),Jinan 250014,China)
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2024年第5期315-320,共6页
Chinese Journal of Nervous and Mental Diseases
基金
国家自然科学基金项目(编号:82101580)
山东省中医药科技发展计划项目(编号:2019-0528)
山东省重点研发计划(科技示范工程)项目(编号:2021SFGC0504)。
