摘要
目的探讨睡眠剥夺与正常睡眠状态下大脑血流灌注特点的差异。资料与方法2020年10月—2021年12月在西安市各高校中招募50例受试者。使用精神运动警觉性任务(PVT)收集持续性注意力行为学数据。采用动脉自旋标记技术比较睡眠剥夺后与正常睡眠后的相对脑血流量(rCBF),分析两种状态下差异脑区的rCBF与PVT脱漏频次差值的相关性。结果与正常睡眠后相比,睡眠剥夺后双侧背外侧前额叶、双侧顶上小叶、左侧眶部额中回、双侧颞中回、右侧中央后回、双侧角回的血流灌注显著减低,而双侧丘脑、左侧楔前叶、右侧内侧前额叶、左侧后扣带回、左侧颞下回的血流灌注明显增高(FDR校正,P<0.05,团块大小≥20体素)。左侧背外侧前额叶及右侧顶上小叶的rCBF变化与PVT脱漏频次差值呈负相关(r=-0.56,P<0.001;r=-0.64,P<0.001),左侧楔前叶的rCBF变化与PVT脱漏频次差值呈正相关(r=0.72,P<0.001)。结论默认网络、额顶网络及丘脑相关脑区血流灌注异常改变可能是睡眠剥夺后持续性注意力下降的重要神经机制。
Purpose To investigate the difference of cerebral blood flow between sleep deprivation and rest wakefulness.Materials and Methods Fifty subjects were recruited from universities in Xi'an from October 2020 to December 2021.The psychomotor vigilance test(PVT)task was used to measure sustained attention.Arterial spin labeling technique was used to analyze and compare the relative cerebral blood flow(rCBF)between sleep deprivation and rest wakefulness.The correlation between altered rCBF of specific brain regions and PVT task performance after sleep deprivation was analyzed.Results Compared with rest wakefulness,rCBF in bilateral dorsolateral prefrontal lobe,bilateral parietal lobule,left orbital middle frontal gyrus,bilateral middle temporal gyrus,right posterior central gyrus,and bilateral angular gyrus was significantly decreased after sleep deprivation.The rCBF of bilateral thalamus,left precuneus,right medial prefrontal lobe,left posterior cingulate gyrus,and left inferior temporal gyrus was significantly increased(FDR corrected,P<0.05,cluster size≥20 voxels).The changes of rCBF in left dorsolateral prefrontal lobe and right parietal lobule were significantly negatively correlated with the PVT task performance(r=-0.56,P<0.001;r=-0.64,P<0.001),and the change of rCBF of left precuneus was significantly positively correlated with the PVT task performance(r=0.72,P<0.001).Conclusion The abnormal changes of CBF in default mode network,frontoparietal network-related brain regions and thalamic may be the important neural mechanism of sustained attentional decline after sleep deprivation.
作者
王潇磊
李磊磊
韩博
孙泽恒
辛轲轲
林港
张蓉
朱元强
白亚妮
WANG Xiaolei;LI Leilei;HAN Bo;SUN Zeheng;XIN Keke;LIN Gang;ZHANG Rong;ZHU Yuanqiang;BAI Yani(Department of Radiology,the First Affiliated Hospital,Air Force Medical University,Xi'an 710032,China;不详)
出处
《中国医学影像学杂志》
CSCD
北大核心
2024年第7期653-658,共6页
Chinese Journal of Medical Imaging
基金
陕西省自然科学基础研究计划项目(2022JM-575)。
关键词
睡眠剥夺
动脉自旋标记
脑血流量
默认模式网络
额顶网络
Sleep deprivation
Arterial spin labeling
Cerebral blood flow
Default mode network
Frontoparietal network
