摘要
碳点是一种新型荧光碳纳米材料,直径一般小于10 nm,具有自发荧光、高生物组织相容性、易于修饰、成本低廉等优点,在生物医学领域拥有广阔的应用前景。眼球因其独特的屏障结构,常规药物停留时间短、穿透性差,通过局部滴眼到达病灶的药物浓度有限,需要增加给药频次以保持药效。另外,糖尿病性黄斑水肿(diabetic macular edema,DME)、脉络膜新生血管(diabetic macular edema,CNV)等疾病的治疗给药则需依赖于玻璃体腔注射,该方法属于有创操作,有引起潜在并发症的可能,且需多次注射,给患者造成了沉重的心理和经济负担。优化眼部给药方法一直是眼科学领域的研究热点。基于碳点的优异特性,碳点在眼部药物递送、眼部成像、眼疾病诊疗中已展现出优秀的应用潜力。本综述将综合介绍碳点的特点及近十年来碳点在眼科疾病诊疗中的研究进展,旨在提供关于碳点在眼科应用现状的系统性认识,为未来研究提供方向。
Carbon dots is a new type of fluorescent carbon nanomaterial,which the diameter is generally less than 10 nm,has the advantages of self-fluorescence,remarkable biocompatibility,easy modification,low cost and so on,has a broad application prospect in the biomedical field.Due to the unique barrier of the eye,conventional drugs have a short residence time and poor penetration,so the concentration of drugs that can reach the lesions through local eye drops is limited,and for what to increase the frequency of administration to maintain efficacy.Up to now,the treatment of posterior eye diseases,such as diabetic macular edema(DME),choroidal neovascularization(CNV)and other diseases still rely on repeated vitreous injection,which is an invasive procedure with potential complications,and need multiple injections,causing a heavy psychological and economic burden on patients.Optimizing the method of ocular drug delivery has always been a hot topic in the field of ophthalmology.Carbon dots have shown excellent application potential in the ocular drug delivery,ocular imaging,and diagnosis and treatment of ocular disease based on its excellent characteristics.This review will systematically introduce the characteristics of carbon dots and the application of carbon dots in the diagnosis and treatment of eye diseases,aiming to provide a comprehensive understanding of the current situation of the application of carbon dots in ophthalmology and provide directions for future research.
作者
赵忆菡(综述)
程亿桐
刘柯宇
李世强
李宛娜
王家伟(审校)
ZHAO Yihan;CHENG Yitong;LIU Keyu;LI Shiqiang;LI Wanna;WANG Jiawei(Department of Ophthalmology,Qilu Hospital of Shandong University,Jinan 250012,China)
出处
《眼科学报》
CAS
2024年第4期210-219,共10页
Eye Science
基金
山东省自然基金项目(ZR2023MH139)。
关键词
碳点
荧光
眼科学
眼部给药
眼部成像
carbon dots
fluorescence
ophthalmology
ocular drug delivery
ocular imaging
