摘要
目的基于血清可溶性白细胞介素2受体(sIL-2R)水平及认知功能变化探究阿立哌唑对酒精中毒性精神障碍患者疗效的影响。方法将医院收治的酒精中毒性精神障碍患者124例,采用随机数字表法分为A组和B组,各62例。A组给予常规治疗;B组给予阿立哌唑初始日剂量10 mg,逐渐增加日剂量至30 mg治疗。治疗结束后比较2组临床疗效,比较治疗前后精神症状、血清相关细胞因子[白细胞介素-2(IL-2)、sIL-2R]、认知功能水平以及生活质量,并分析B组患者治疗后血清sIL-2R水平与上述指标的相关性。结果治疗后B组阳性症状、阴性症状和一般精神病理得分分别为(10.04±2.98)、(8.12±1.37)、(21.56±2.71)分,均低于A组的(13.81±2.24)、(13.73±2.01)、(26.74±3.12)分,差异均有统计学意义(P<0.05)。治疗后B组正确应答数和完成分类数多于A组,而错误应答数则少于A组,差异均有统计学意义(P<0.05)。B组临床总疗效优于A组(P<0.05)。治疗后B组血清IL-2和sIL-2R水平分别为(25.41±3.85)、(72.61±8.10)pg·mL^(-1)均低于A组的(31.26±4.08)、(89.43±8.26)pg·mL^(-1)(P<0.05)。B组患者治疗后血清sIL-2R水平与精神症状阳性与阴性症状量表评量各项评分和错误应答数均呈正相关(P<0.05),与正确应答数、完成分类数和生活质量各项评分之间均呈负相关(P<0.05)。B组患者治疗后血清sIL-2R水平与临床疗效呈负相关(P<0.05)。结论阿立哌唑治疗酒精中毒性精神障碍疗效显著,可有效降低患者血清sIL-2R水平,改善认知功能和生活质量,且血清sIL-2R水平与患者临床疗效、精神症状、认知功能和生活质量密切相关。
AIM To explore the influence of aripiprazole on efficacy of patients with alcoholism-induced mental disorders based on the changes of serum soluble interleukin-2 receptor(sIL-2R)and cognitive function.METHODS A total of 124 patients with alcoholism-induced mental disorders in the hospital were divided into group A and group B by random number table method,with 62 cases in each group.Group A was given routine treatment,and group B was treated with aripiprazole at an initial dose of 10 mg·d^(-1)and gradually increased to 30 mg·d^(-1).The clinical efficacy and mental symptoms,levels of serum-related cytokines[interleukin-2(IL-2),sIL-2R],cognitive function and quality of life before and after treatment were compared between 2 groups.The correlation between serum sIL-2R level and the above indicators in group B after treatment was analyzed.RESULTS The scores of positive symptom,negative symptom and general psychopathology in group B after treatment were(10.04±2.98),(8.12±1.37)and(21.56±2.71)points,all of which were lower than the scores in group A(13.81±2.24),(13.73±2.01)and(26.74±3.12)points in group A,with significant differences(P<0.05).After treatment,the number of correct responses and the number of completed classifications in group B were more than those in group A while the number of incorrect responses was less than that in group A,with significant differences(P<0.05).The total clinical efficacy in group B was better than that in group A(P<0.05).After treatment,the levels of serum IL-2 and sIL-2R in group B were(25.41±3.85)and(72.61±8.10)pg·mL^(-1),which were lower than those in group A(31.26±4.08)and(89.43±8.26)pg·mL^(-1)(P<0.05).After treatment,the level of serum sIL-2R in group B was positively correlated with the scores of positive and negative symptoms scale and the number of incorrect responses(P<0.05),and was negatively correlated with the number of correct responses,the number of completed classification and all scores of items of quality of life(P<0.05).In group B,serum sIL-2R level after treatment was negatively correlated with clinical efficacy(P<0.05).CONCLUSION Aripiprazole has significant efficacy in the treatment of alcoholism-induced mental disorder,which can effectively reduce the level of serum sIL-2R and improve the cognitive function and quality of life of patients,and the level of serum sIL-2R is closely related to the clinical efficacy,mental symptoms,cognitive function and quality of life of patients.
作者
余春柳
王文岭
YU Chunliu;WANG Wenling(Department of Material Dependence,Hainan Anning Hospital,Haikou 570206,China;School of Information and Communication Engineering,Hainan University,Haikou 570228,China)
出处
《中国临床药学杂志》
CAS
2024年第4期279-284,共6页
Chinese Journal of Clinical Pharmacy
